PMID- 24377440
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20220310
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 215
IP  - 2
DP  - 2014 Feb 28
TI  - A positive correlation between serum levels of mature brain-derived neurotrophic 
      factor and negative symptoms in schizophrenia.
PG  - 268-73
LID - S0165-1781(13)00772-5 [pii]
LID - 10.1016/j.psychres.2013.12.009 [doi]
AB  - A meta-analysis study reported serum brain-derived neurotrophic factor (BDNF) 
      levels as a potential biomarker for schizophrenia. However, at the time, 
      commercially available human ELISA kits were unable to distinguish between 
      pro-BDNF (precursor BDNF) and mature BDNF, because of limited antibody 
      specificity. Here, we used new ELISA kits, to examine serum levels of mature BDNF 
      and matrix metalloproteinase-9 (MMP-9), which converts pro-BDNF to mature BDNF in 
      schizophrenia. Sixty-three patients with chronic schizophrenia and 52 age- and 
      sex-matched healthy controls were enrolled. Patients were evaluated using the 
      Brief Psychiatry Rating Scale, the Scale for the Assessment of Negative Symptoms 
      (SANS) and neuropsychological tests. Neither serum mature BDNF nor MMP-9 levels 
      differed between patients and controls. In male subgroups, serum MMP-9 levels of 
      smoking patients were higher than those of non-smoking patients, but this was not 
      observed in male controls or the female subgroup. In patients, serum mature BDNF 
      levels were associated with SANS total scores and the Information subtest scores 
      of the Wechsler Adult Intelligence Scale Revised (WAIS-R), while serum MMP-9 
      levels were associated with smoking and category fluency scores. These findings 
      suggest that neither mature BDNF nor MMP-9 is a suitable biomarker for 
      schizophrenia, although further studies using large samples are needed.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Niitsu, Tomihisa
AU  - Niitsu T
AD  - Research Center for Child Mental Development, Chiba University Graduate School of 
      Medicine, Chiba, Japan. Electronic address: niitsu@chiba-u.jp.
FAU - Ishima, Tamaki
AU  - Ishima T
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, Japan.
FAU - Yoshida, Taisuke
AU  - Yoshida T
AD  - Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, 
      Japan.
FAU - Hashimoto, Tasuku
AU  - Hashimoto T
AD  - Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, 
      Japan.
FAU - Matsuzawa, Daisuke
AU  - Matsuzawa D
AD  - Research Center for Child Mental Development, Chiba University Graduate School of 
      Medicine, Chiba, Japan; Department of Cognitive Behavioral Physiology, Chiba 
      University Graduate School of Medicine, Chiba, Japan.
FAU - Shirayama, Yukihiko
AU  - Shirayama Y
AD  - Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, 
      Japan.
FAU - Nakazato, Michiko
AU  - Nakazato M
AD  - Research Center for Child Mental Development, Chiba University Graduate School of 
      Medicine, Chiba, Japan.
FAU - Shimizu, Eiji
AU  - Shimizu E
AD  - Research Center for Child Mental Development, Chiba University Graduate School of 
      Medicine, Chiba, Japan; Department of Cognitive Behavioral Physiology, Chiba 
      University Graduate School of Medicine, Chiba, Japan.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, Japan.
FAU - Iyo, Masaomi
AU  - Iyo M
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, Japan; Department of Psychiatry, Chiba University Graduate School 
      of Medicine, Chiba, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131214
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 9/blood
MH  - Neuropsychological Tests
MH  - Schizophrenia/*blood
MH  - Schizophrenic Psychology
MH  - Sex Factors
OTO - NOTNLM
OT  - Biomarker
OT  - ELISA
OT  - Gender
OT  - MMP-9
OT  - Mature BDNF
OT  - SANS
OT  - Smoking
EDAT- 2014/01/01 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/01 06:00
PHST- 2013/04/27 00:00 [received]
PHST- 2013/09/11 00:00 [revised]
PHST- 2013/12/05 00:00 [accepted]
PHST- 2014/01/01 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0165-1781(13)00772-5 [pii]
AID - 10.1016/j.psychres.2013.12.009 [doi]
PST - ppublish
SO  - Psychiatry Res. 2014 Feb 28;215(2):268-73. doi: 10.1016/j.psychres.2013.12.009. 
      Epub 2013 Dec 14.