PMID- 24377704
OWN - NLM
STAT- MEDLINE
DCOM- 20141105
LR  - 20140303
IS  - 1939-6376 (Electronic)
IS  - 1939-6368 (Linking)
VI  - 60
IP  - 2
DP  - 2014 Apr
TI  - Increased IVF pregnancy rates after microarray preimplantation genetic diagnosis 
      due to parental translocations.
PG  - 119-24
LID - 10.3109/19396368.2013.875241 [doi]
AB  - We successfully performed preimplantation genetic diagnosis (PGD) and 
      simultaneous preimplantation genetic screening (PGS) using single nucleotide 
      polymorphism (SNP) microarrays for couples with balanced chromosome 
      rearrangements in China. A total of 428 molecular karyotypes were diagnosed from 
      62 couples undergoing 68 in vitro fertilization (IVF) cycles. Of these, 48.1% of 
      the embryos were chromosomally normal without translocation errors or aneuploidy. 
      Of the 428 total embryos, 18.0% embryos were euploid, but were imbalanced due to 
      the transmission of single translocation chromosome derivatives. A total of 6.5% 
      of the embryos had chromosome abnormalities involving the parental chromosome 
      aberration and other chromosomes aneuploidies. Significantly, 27.4% of the 
      embryos were normal/balanced for the rearranged chromosomes, but were abnormal 
      due to aneuploidy affecting other chromosomes. When evaluated on a per IVF cycle 
      basis, 84% of the cycles had at least one chromosomally normal embryo available 
      for uterine transfer. The clinical pregnancy rate per IVF cycle was 54%. 
      Diagnosing genomically balanced embryos through 24 chromosome SNP microarray 
      PGD/PGS, rather than minimally targeted fluorescence in situ hybridization 
      (FISH), is a promising strategy to maximize the pregnancy potential of patients 
      with known parental chromosomal translocations. Moreover, this is the first study 
      to report the clinical application of SNP arrays to screen all 24 chromosome 
      pairs of blastomeres and trophectoderm cells from patients carrying reciprocal 
      translocations in China.
FAU - Li, Gang
AU  - Li G
AD  - Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou 
      University , Zhengzhou , China .
FAU - Jin, Haixia
AU  - Jin H
FAU - Xin, Zhimin
AU  - Xin Z
FAU - Su, Yingchun
AU  - Su Y
FAU - Brezina, Paul R
AU  - Brezina PR
FAU - Benner, Andrew T
AU  - Benner AT
FAU - Kearns, William G
AU  - Kearns WG
FAU - Sun, Yingpu
AU  - Sun Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131230
PL  - England
TA  - Syst Biol Reprod Med
JT  - Systems biology in reproductive medicine
JID - 101464963
SB  - IM
MH  - Female
MH  - *Fertilization in Vitro
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - *Pregnancy Rate
MH  - *Preimplantation Diagnosis
MH  - *Translocation, Genetic
EDAT- 2014/01/01 06:00
MHDA- 2014/11/06 06:00
CRDT- 2014/01/01 06:00
PHST- 2014/01/01 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2014/11/06 06:00 [medline]
AID - 10.3109/19396368.2013.875241 [doi]
PST - ppublish
SO  - Syst Biol Reprod Med. 2014 Apr;60(2):119-24. doi: 10.3109/19396368.2013.875241. 
      Epub 2013 Dec 30.