PMID- 24378057
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20131231
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 52
IP  - 10
DP  - 2013 Oct
TI  - [Clinical characteristics of late-onset severe pneumonia after allogeneic 
      hematopoietic stem cell transplantation].
PG  - 819-23
AB  - OBJECTIVE: To analyze the clinical characteristics of the late-onset severe 
      pneumonia after allogeneic hematopoietic stem cell transplantation (allo-HSCT). 
      METHODS: A retrospective study was conducted in patients diagnosed as late-onset 
      severe pneumonia after allo-HSCT from March, 2009 to January, 2013 in People's 
      Hospital of Peking University. RESULTS: Of 1538 patients receiving allo-HSCT, 20 
      developed late-onset severe pneumonia with an incidence rate of 1.3%. Among the 
      20 patients, 17(85%) had human leukocyte antigen (HLA) identical donors. The 
      other 3(15%) patients had received haplo-identical transplantation. Severe 
      pneumonia occurred at a median time of 227(150-690) days after allo-HSCT. Blood 
      gas tests showed that 14 patients (70%) had arterial oxygen lower than 60 mm Hg 
      (1 mm Hg = 0.133 kPa). All patients had abnormal findings in chest X-ray or CT 
      scan images, 18 (90%) of whom represented bilateral infiltrative lesions. None of 
      the patients had evidence of active graft-versus-host disease before or during 
      pneumonia. Eighteen patients did not respond to empiric antibiotics, neither did 
      8 patients to targeted medications who had positive pathogens by culture. Eleven 
      patients died of respiratory failure and 9 survived. Six patients received donor 
      lymphocyte infusion (DLI), 4 of whom obtained improvement of chest images and 3 
      survived till the end of follow-up. CONCLUSIONS: The late-onset severe pneumonia 
      after allo-HSCT represents an aggressive behavior with poor prognosis. DLI might 
      be an effective way to improve its outcome.
FAU - Liu, Dai-hong
AU  - Liu DH
AD  - Institute of Hematology and People's Hospital, Peking University, Beijing 100044, 
      China.
FAU - Chen, Su-shan
AU  - Chen SS
AD  - Institute of Hematology and People's Hospital, Peking University, Beijing 100044, 
      China.
FAU - Sun, Yu-qian
AU  - Sun YQ
AD  - Institute of Hematology and People's Hospital, Peking University, Beijing 100044, 
      China.
FAU - Wang, Jing-zhi
AU  - Wang JZ
AD  - Institute of Hematology and People's Hospital, Peking University, Beijing 100044, 
      China.
FAU - Wang, Feng-rong
AU  - Wang FR
AD  - Institute of Hematology and People's Hospital, Peking University, Beijing 100044, 
      China.
FAU - Zhang, Xiao-hui
AU  - Zhang XH
AD  - Institute of Hematology and People's Hospital, Peking University, Beijing 100044, 
      China.
FAU - Xu, Lan-ping
AU  - Xu LP
AD  - Institute of Hematology and People's Hospital, Peking University, Beijing 100044, 
      China.
FAU - Huang, Xiao-Jun
AU  - Huang XJ
AD  - Institute of Hematology and People's Hospital, Peking University, Beijing 100044, 
      China. Email:huangxiaojun@bjmu.edu.cn.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects/methods
MH  - Humans
MH  - Middle Aged
MH  - Pneumonia/*epidemiology
MH  - Retrospective Studies
MH  - Transplantation, Homologous
MH  - Young Adult
EDAT- 2014/01/01 06:00
MHDA- 2015/02/13 06:00
CRDT- 2014/01/01 06:00
PHST- 2014/01/01 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2013 Oct;52(10):819-23.