PMID- 24378753
OWN - NLM
STAT- MEDLINE
DCOM- 20140917
LR  - 20220408
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Linking)
VI  - 28
IP  - 4
DP  - 2014 Feb 20
TI  - Elevated IP10 levels are associated with immune activation and low CD4(+) T-cell 
      counts in HIV controller patients.
PG  - 467-76
LID - 10.1097/QAD.0000000000000174 [doi]
AB  - BACKGROUND: Although HIV controllers (HICs) achieve long-term control of viremia 
      in the absence of antiretroviral therapy (ART), they display marked immune 
      activation. The levels of inflammatory biomarkers in HICs and the biomarkers' 
      relationships with immunologic and virologic status have yet to be fully 
      characterized. DESIGN: A cohort study. METHODS: Plasma levels of seven biomarkers 
      [tumor necrosis factor (TNF)alpha, interleukin (IL)6, IL10, interferon gamma-induced 
      protein 10 (IP10), monocyte chemoattractant protein-1 (MCP1), soluble CD14 
      (sCD14), soluble CD163 (sCD163)] were compared in 70 HICs, 33 HIV-1-infected, 
      treatment-naive noncontrollers (viremic patients), 30 ART-treated patients and 40 
      healthy donors. In HICs, we investigated the interplay between biomarkers, cell 
      activation and the CD4(+) T-cell count. RESULTS: HICs had higher levels of IP10, 
      TNFalpha and sCD14 than healthy donors did (P < 0.01 for each). Also, TNFalpha and sCD14 
      levels of the HICs were similar to those measured in viremic and ART-treated 
      patients. However, the levels of IL6 and IL10 were significantly lower in HICs 
      than in viremic or ART-treated patients. In HICs, only IP10 levels differed 
      significantly from those in both healthy donors and viremic patients, and were 
      positively correlated with the expression of CD8(+) and CD4(+) T-cell activation 
      markers. The IP10 levels of HICs were still elevated 12 and 24 months after the 
      initial assay. Lastly, IP10 levels at enrollment were negatively correlated with 
      the CD4(+) T-cell count at enrollment and 12 months later. CONCLUSION: HICs display 
      a number of inflammatory features associated with persistent T-cell immune 
      activation.
FAU - Noel, Nicolas
AU  - Noel N
AD  - aINSERM U1012, Regulation de la reponse immune, infection VIH1 et autoimmunite, 
      Universite Paris Sud bAPHP, Service de Medecine Interne, Hopitaux Universitaires 
      Paris Sud cINSERM U1018, Centre de recherche en Epidemiologie et Sante des 
      Populations, Universite Paris Sud, Le Kremlin Bicetre dInstitut Pasteur, Unite de 
      regulation des infections retrovirales, Paris eService de Microbiologie, CHU 
      Caremeau fINSERM U1047, Centre National de Reference des Brucella (L.A.), UFR de 
      Medecine Universite Montpellier 1, Nimes gFaculte de Medecine Paris Sud XI, Le 
      Kremlin Bicetre hAPHP, Laboratoire de Virologie, CHU Necker, Paris, France.
FAU - Boufassa, Faroudy
AU  - Boufassa F
FAU - Lecuroux, Camille
AU  - Lecuroux C
FAU - Saez-Cirion, Asier
AU  - Saez-Cirion A
FAU - Bourgeois, Christine
AU  - Bourgeois C
FAU - Dunyach-Remy, Catherine
AU  - Dunyach-Remy C
FAU - Goujard, Cecile
AU  - Goujard C
FAU - Rouzioux, Christine
AU  - Rouzioux C
FAU - Meyer, Laurence
AU  - Meyer L
FAU - Pancino, Gianfranco
AU  - Pancino G
FAU - Venet, Alain
AU  - Venet A
FAU - Lambotte, Olivier
AU  - Lambotte O
CN  - ANRS C021 CODEX Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (Biomarkers)
RN  - 0 (CXCL10 protein, human)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Chemokine CXCL10/*blood
MH  - Cohort Studies
MH  - Cytokines/*blood
MH  - Disease Progression
MH  - Female
MH  - HIV Infections/*immunology/*pathology
MH  - *HIV Long-Term Survivors
MH  - Humans
MH  - *Lymphocyte Activation
MH  - Male
MH  - Middle Aged
EDAT- 2014/01/01 06:00
MHDA- 2014/09/18 06:00
CRDT- 2014/01/01 06:00
PHST- 2014/01/01 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2014/09/18 06:00 [medline]
AID - 10.1097/QAD.0000000000000174 [doi]
PST - ppublish
SO  - AIDS. 2014 Feb 20;28(4):467-76. doi: 10.1097/QAD.0000000000000174.