PMID- 24379221
OWN - NLM
STAT- MEDLINE
DCOM- 20170104
LR  - 20170105
IS  - 1544-2217 (Electronic)
IS  - 0300-9858 (Linking)
VI  - 51
IP  - 6
DP  - 2014 Nov
TI  - Processionary caterpillar setae and equine fetal loss: 1. Histopathology of 
      experimentally exposed pregnant mares.
PG  - 1117-30
LID - 10.1177/0300985813516638 [doi]
AB  - Six pregnant Standardbred mares aged between 6 and 14 years were gavaged with 50 
      g or 100 g of suspended emulsified whole Processionary caterpillars (Ochrogaster 
      lunifer) for 5 days during 2 experiments undertaken to study the etiology of 
      equine amnionitis and fetal loss (EAFL). The 6 treated mares and 1 untreated mare 
      were between 128 and 252 days gestation. Mare 1 (untreated) was euthanized on day 
      5 of the treatment period, while the treated mares were euthanized on days 2, 4, 
      8, 10, 12, and 24 days from their first treatment. Caterpillar setae were not 
      found in the untreated mare. Setal fragments were present in all regions of the 
      gastrointestinal tracts in all treated mares, the uteri and mesenteric lymph 
      nodes of 5 mares, and the liver of 4 mares. Acute gastroenteritis of varying 
      severity was present in all treated mares, and 5 of 6 mares had acute colitis and 
      endometritis. Focal hyperplastic serositis was found in the duodenum, cecum, 
      dorsal colon, and uteri of various mares occasionally with embedded setal 
      fragments. Setal invasion of the mucosa evoked a range of lesions including 
      superficial erosion to deep ulceration. Inflammation in deeper tissues ranged 
      from unapparent to neutrophilic (microabscesses), eosinophilic, or mononuclear 
      (microgranulomas). The finding of setal fragments within the uterus of 
      experimental mares suggests that direct migration of setal fragments acting as a 
      bacterial vector is a likely mechanism for the bacterial abortions that 
      characterize equine amnionitis and fetal loss.
CI  - (c) The Author(s) 2013.
FAU - Todhunter, K H
AU  - Todhunter KH
AD  - Equine Research Unit, School of Agriculture and Food Sciences, The University of 
      Queensland, Gatton Queensland, Australia todhunter@westnet.com.au.
FAU - Cawdell-Smith, A J
AU  - Cawdell-Smith AJ
AD  - Equine Research Unit, School of Agriculture and Food Sciences, The University of 
      Queensland, Gatton Queensland, Australia.
FAU - Bryden, W L
AU  - Bryden WL
AD  - Equine Research Unit, School of Agriculture and Food Sciences, The University of 
      Queensland, Gatton Queensland, Australia.
FAU - Perkins, N R
AU  - Perkins NR
AD  - Equine Research Unit, School of Agriculture and Food Sciences, The University of 
      Queensland, Gatton Queensland, Australia AusVet Animal Health Services, 
      Toowoomba, Queensland, Australia.
FAU - Begg, A P
AU  - Begg AP
AD  - Vetnostics, North Ryde, New South Wales, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131230
PL  - United States
TA  - Vet Pathol
JT  - Veterinary pathology
JID - 0312020
SB  - IM
MH  - Aborted Fetus/microbiology/pathology
MH  - *Abortion, Veterinary
MH  - Animals
MH  - Chorioamnionitis/microbiology/pathology/*veterinary
MH  - Female
MH  - Fetal Death
MH  - Gastroenteritis/microbiology/pathology/*veterinary
MH  - Horse Diseases/microbiology/*pathology
MH  - Horses
MH  - Moths/microbiology/*physiology
MH  - Pregnancy
MH  - Sensilla/*microbiology
OTO - NOTNLM
OT  - EAFL
OT  - abortion
OT  - caterpillars
OT  - equine
OT  - fetal
OT  - histopathology
OT  - mare
OT  - setae
EDAT- 2014/01/01 06:00
MHDA- 2017/01/05 06:00
CRDT- 2014/01/01 06:00
PHST- 2014/01/01 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2017/01/05 06:00 [medline]
AID - 0300985813516638 [pii]
AID - 10.1177/0300985813516638 [doi]
PST - ppublish
SO  - Vet Pathol. 2014 Nov;51(6):1117-30. doi: 10.1177/0300985813516638. Epub 2013 Dec 
      30.