PMID- 24379269
OWN - NLM
STAT- MEDLINE
DCOM- 20140529
LR  - 20191112
IS  - 1732-2693 (Electronic)
IS  - 0032-5449 (Linking)
VI  - 67
DP  - 2013 Dec 11
TI  - [The role of peroxisome proliferator-activated receptors gamma (PPARgamma) in obesity and 
      insulin resistance].
PG  - 1283-99
AB  - Obesity, defined as abnormal or excessive fat accumulation, is currently believed 
      to be a major public health problem worldwide. Over the past 20 years, the 
      prevalence of obesity has increased rapidly in both industrialized and developing 
      countries, resulting in a considerably increased risk of type 2 diabetes mellitus 
      (T2DM) and metabolic syndrome. Although the exact pathophysiological mechanisms 
      underlying these diseases remain unclear, clinical and epidemiological studies 
      support the existence of a relationship between obesity-induced inflammation and 
      insulin resistance linked with the development and progression of metabolic 
      diseases. Adipokines, produced and released by adipose tissue, are considered as 
      factors linking obesity-induced inflammation with insulin resistance, and their 
      regulation through peroxisome proliferator-activated receptors gamma (PPARgamma also 
      known as NR1C3) is essential in these processes. PPARgamma are transcriptional 
      factors belonging to the ligand-activated nuclear receptor superfamily which 
      directly regulate the expression of a large number of genes involved in adipocyte 
      differentiation, lipid and carbohydrate metabolism as well as adipokine 
      synthesis; thereby they are implicated in various metabolic disorders, including 
      obesity, insulin resistance, dyslipidemia, and hypertension. This review 
      summarizes the current literature on a functional relationship of PPARgamma with 
      obesity and insulin resistance and, moreover, highlights the significance of 
      synthetic ligands of these receptors in the mentioned metabolic disorders.
FAU - Chmielewska-Kassassir, Malgorzata
AU  - Chmielewska-Kassassir M
AD  - Zaklad Biologii Strukturalnej, Uniwersytet Medyczny w Lodzi.
FAU - Wozniak, Lucyna A
AU  - Wozniak LA
AD  - Zaklad Biologii Strukturalnej, Uniwersytet Medyczny w Lodzi.
FAU - Ogrodniczek, Pawel
AU  - Ogrodniczek P
AD  - Zaklad Biologii Strukturalnej, Uniwersytet Medyczny w Lodzi.
FAU - Wojcik, Marzena
AU  - Wojcik M
AD  - Zaklad Biologii Strukturalnej, Uniwersytet Medyczny w Lodzi.
LA  - pol
PT  - Journal Article
PT  - Review
TT  - Rola receptorow aktywowanych przez proliferatory peroksysomow gamma (PPARgamma) w 
      otylosci i insulinoopornosci.
DEP - 20131211
PL  - Poland
TA  - Postepy Hig Med Dosw (Online)
JT  - Postepy higieny i medycyny doswiadczalnej (Online)
JID - 101206517
RN  - 0 (Adipokines)
RN  - 0 (PPAR gamma)
RN  - 0 (Peroxisome Proliferator-Activated Receptors)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adipokines/metabolism
MH  - Adipose Tissue/*metabolism
MH  - Diabetes Mellitus, Type 2/complications/metabolism
MH  - Humans
MH  - Hypertension/complications/metabolism
MH  - Inflammation/complications/metabolism
MH  - Insulin Resistance/*physiology
MH  - Metabolic Syndrome/metabolism
MH  - Obesity/complications/*metabolism
MH  - PPAR gamma/*metabolism
MH  - Peroxisome Proliferator-Activated Receptors/metabolism
MH  - Receptors, Cytoplasmic and Nuclear/metabolism
MH  - Transcription Factors/metabolism
EDAT- 2014/01/01 06:00
MHDA- 2014/05/30 06:00
CRDT- 2014/01/01 06:00
PHST- 2014/01/01 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2014/05/30 06:00 [medline]
AID - 1080028 [pii]
AID - 10.5604/17322693.1080028 [doi]
PST - epublish
SO  - Postepy Hig Med Dosw (Online). 2013 Dec 11;67:1283-99. doi: 
      10.5604/17322693.1080028.