PMID- 24379800
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131231
LR  - 20240323
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 4
DP  - 2013
TI  - Comparison of visual evoked potentials and retinal nerve fiber layer thickness in 
      Alzheimer's disease.
PG  - 203
LID - 10.3389/fneur.2013.00203 [doi]
LID - 203
AB  - INTRODUCTION: Alzheimer's disease (AD) is a long term progressive 
      neurodegenerative disease and might affect the retinal nerve fiber layer 
      thickness (RNFLT) of the eye. There is increasing evidence that visual evoked 
      potentials (VEP), which are an objective way to indicate visual field loss, might 
      be affected by the disease as well. MATERIALS AND METHODS: About 22 patients 
      (mean age: 75.9 +/- 6.1 years; 14 women) with mild-to-moderate AD and 22 
      sex-matched healthy patients were examined. We compared the use of VEP and RNFLT 
      using the latest high-resolution spectral domain optical coherence tomography 
      with eye-tracking capabilities for optimized peripapillary scan centering for the 
      first time in AD patients. RESULTS: The mean MMSE score was 22.59 +/- 5.47 in the 
      AD group, and did not significantly correlate with the VEP latencies. We found no 
      significant difference between the VEP latencies of the AD patients and those of 
      the control patients. No peripapillary sector of the retina had a RNFLT 
      significantly correlated with the VEP latencies. DISCUSSION: We demonstrated that 
      pattern VEP did not show any significant correlation despite subtle loss in 
      RNFLT. It remains open whether additional flash VEP combined with RNFLT analysis 
      may be useful in diagnosing AD, particularly for mild-to-moderate stages of the 
      disease.
FAU - Kromer, Robert
AU  - Kromer R
AD  - Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University 
      Heidelberg , Mannheim , Germany.
FAU - Serbecic, Nermin
AU  - Serbecic N
AD  - Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University 
      Heidelberg , Mannheim , Germany.
FAU - Hausner, Lucrezia
AU  - Hausner L
AD  - Division of Geriatric Psychiatry, Central Institute of Mental Health, Medical 
      Faculty Mannheim, Ruprecht-Karls-University Heidelberg , Mannheim , Germany.
FAU - Froelich, Lutz
AU  - Froelich L
AD  - Division of Geriatric Psychiatry, Central Institute of Mental Health, Medical 
      Faculty Mannheim, Ruprecht-Karls-University Heidelberg , Mannheim , Germany.
FAU - Beutelspacher, Sven C
AU  - Beutelspacher SC
AD  - Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University 
      Heidelberg , Mannheim , Germany.
LA  - eng
PT  - Journal Article
DEP - 20131216
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC3864196
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - dementia
OT  - optical coherence tomography
OT  - retinal nerve fiber layer thickness
OT  - visual evoked potentials
EDAT- 2014/01/01 06:00
MHDA- 2014/01/01 06:01
PMCR- 2013/12/16
CRDT- 2014/01/01 06:00
PHST- 2013/10/05 00:00 [received]
PHST- 2013/12/03 00:00 [accepted]
PHST- 2014/01/01 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2014/01/01 06:01 [medline]
PHST- 2013/12/16 00:00 [pmc-release]
AID - 10.3389/fneur.2013.00203 [doi]
PST - epublish
SO  - Front Neurol. 2013 Dec 16;4:203. doi: 10.3389/fneur.2013.00203. eCollection 2013.