PMID- 24380884
OWN - NLM
STAT- MEDLINE
DCOM- 20141016
LR  - 20140221
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 75
DP  - 2014 Apr
TI  - Influence of feeding state on neurofunctional differences between individuals who 
      are obese and normal weight: a meta-analysis of neuroimaging studies.
PG  - 103-9
LID - S0195-6663(13)00504-7 [pii]
LID - 10.1016/j.appet.2013.12.017 [doi]
AB  - Obesity is a complex disorder associated with serious health risks. Examining 
      differences in brain activity between normal weight and obese populations in 
      response to food cues may help researchers and clinicians understand the 
      underlying causes of overeating and obesity and help prevent them. Multiple 
      neuroimaging studies have investigated weight differences in functional activity 
      to food cues but have found varying results. We performed six meta-analyses of 
      functional neuroimaging studies of weight differences in response to food images 
      and isolated differences in processing between normal weight and obese 
      participants. Within this study, 7 papers and 3 sets of unpublished data on 
      functional activation to food images were analyzed using an Activation Likelihood 
      Estimation meta-analytic approach. These analyses also addressed how feeding 
      state impacts functional activity between weight groups. Feeding state affected 
      weight related differences in neurofunctional activity triggered by visual food 
      cues. In the premeal state, greater activation in the amygdala/hippocampus was 
      found in obese participants compared to normal weight participants and, in the 
      postmeal state, obese individuals had greater activation in the caudate and 
      medial prefrontal cortex (MPFC) as compared to normal weight individuals. Regions 
      of the brain associated with caloric evaluation, arousal, and memory were more 
      active in the obese before eating, while less activity was found in an area 
      linked to interoceptive processing. In the postmeal state, greater activity was 
      found in the obese in areas related to risk vs. reward evaluation and reward 
      processing. These findings may help researchers and clinicians understand and 
      treat obesity related behaviors by identifying the altered functional regions 
      that lead to obesity, providing a guide for future research on which neural 
      regions need to be the target of further investigation.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Kennedy, James
AU  - Kennedy J
AD  - Department of Psychology, Case Western Reserve University, 10900 Euclid Avenue, 
      Cleveland, OH 44106-7123, USA. Electronic address: james.kennedy1@case.edu.
FAU - Dimitropoulos, Anastasia
AU  - Dimitropoulos A
AD  - Department of Psychology, Case Western Reserve University, 10900 Euclid Avenue, 
      Cleveland, OH 44106-7123, USA. Electronic address: 
      anastasia.dimitropoulos@case.edu.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20131228
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
SB  - IM
MH  - Amygdala/metabolism
MH  - Body Weight/*physiology
MH  - Cues
MH  - Eating
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Hyperphagia/metabolism
MH  - Likelihood Functions
MH  - *Neuroimaging
MH  - Neurons/*metabolism
MH  - Obesity/*metabolism
MH  - Postprandial Period/physiology
MH  - Prefrontal Cortex/metabolism
OTO - NOTNLM
OT  - Feeding state
OT  - Food
OT  - Meta-analysis
OT  - Neuroimaging
OT  - Obesity
EDAT- 2014/01/02 06:00
MHDA- 2014/10/17 06:00
CRDT- 2014/01/02 06:00
PHST- 2013/09/30 00:00 [received]
PHST- 2013/12/03 00:00 [revised]
PHST- 2013/12/21 00:00 [accepted]
PHST- 2014/01/02 06:00 [entrez]
PHST- 2014/01/02 06:00 [pubmed]
PHST- 2014/10/17 06:00 [medline]
AID - S0195-6663(13)00504-7 [pii]
AID - 10.1016/j.appet.2013.12.017 [doi]
PST - ppublish
SO  - Appetite. 2014 Apr;75:103-9. doi: 10.1016/j.appet.2013.12.017. Epub 2013 Dec 28.