PMID- 24380900
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20181202
IS  - 1523-1755 (Electronic)
IS  - 0085-2538 (Linking)
VI  - 85
IP  - 1
DP  - 2014 Jan
TI  - The endothelium as part of the integrative glomerular barrier complex.
PG  - 8-11
LID - 10.1038/ki.2013.317 [doi]
AB  - A new study by Xu et al. presents compelling evidence for an important role of 
      the glomerular endothelium in acute kidney injury. They show that 
      lipopolysaccharide reduces the endothelial surface layer, resulting in mild 
      albuminuria, reduced glomerular filtration rate, and fewer endothelial fenestrae. 
      Tumor necrosis factor-alpha (TNF-alpha) is identified as instrumental in these 
      lipopolysaccharide effects through the TNF-alpha type 1 receptor. The study 
      highlights that the glomerular endothelium has a key role in the maintenance of 
      the glomerular filtration barrier.
FAU - Haraldsson, Borje S
AU  - Haraldsson BS
AD  - 1] Institute of Medicine, University of Gothenburg, Nephrology, Sahlgrenska 
      University Hospital, Gothenburg, Sweden [2] Department of Medicine, Icahn School 
      of Medicine at Mount Sinai, New York, New York, USA.
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
CON - Kidney Int. 2014 Jan;85(1):72-81. PMID: 23903370
MH  - Acute Kidney Injury/*etiology
MH  - Animals
MH  - Kidney Glomerulus/*physiopathology
MH  - Male
MH  - Sepsis/*complications
MH  - Tumor Necrosis Factor-alpha/*physiology
MH  - Urothelium/*physiopathology
EDAT- 2014/01/02 06:00
MHDA- 2014/09/30 06:00
CRDT- 2014/01/02 06:00
PHST- 2014/01/02 06:00 [entrez]
PHST- 2014/01/02 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
AID - S0085-2538(15)56152-8 [pii]
AID - 10.1038/ki.2013.317 [doi]
PST - ppublish
SO  - Kidney Int. 2014 Jan;85(1):8-11. doi: 10.1038/ki.2013.317.