PMID- 24381545
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140101
LR  - 20211021
IS  - 1662-5137 (Print)
IS  - 1662-5137 (Electronic)
IS  - 1662-5137 (Linking)
VI  - 7
DP  - 2013
TI  - Resting state low-frequency fluctuations in prefrontal cortex reflect degrees of 
      harm avoidance and novelty seeking: an exploratory NIRS study.
PG  - 115
LID - 10.3389/fnsys.2013.00115 [doi]
LID - 115
AB  - Harm avoidance (HA) and novelty seeking (NS) are temperament dimensions defined 
      by Temperament and Character Inventory (TCI), respectively, reflecting a 
      heritable bias for intense response to aversive stimuli or for excitement in 
      response to novel stimuli. High HA is regarded as a risk factor for major 
      depressive disorder and anxiety disorder. In contrast, higher NS is linked to 
      increased risk for substance abuse and pathological gambling disorder. A growing 
      body of evidence suggests that patients with these disorders show abnormality in 
      the power of slow oscillations of resting-state brain activity. It is 
      particularly interesting that previous studies have demonstrated that resting 
      state activities in medial prefrontal cortex (MPFC) are associated with HA or NS 
      scores, although the relation between the power of resting state slow 
      oscillations and these temperament dimensions remains poorly elucidated. This 
      preliminary study investigated the biological bases of these temperament traits 
      by particularly addressing the resting state low-frequency fluctuations in MPFC. 
      Regional hemodynamic changes in channels covering MPFC during 5-min resting 
      states were measured from 22 healthy participants using near-infrared 
      spectroscopy (NIRS). These data were used for correlation analyses. Results show 
      that the power of slow oscillations during resting state around the dorsal part 
      of MPFC is negatively correlated with the HA score. In contrast, NS was 
      positively correlated with the power of resting state slow oscillations around 
      the ventral part of MPFC. These results suggest that the powers of slow 
      oscillation at rest in dorsal or ventral MPFC, respectively, reflect the degrees 
      of HA and NS. This exploratory study therefore uncovers novel neural bases of HA 
      and NS. We discuss a neural mechanism underlying aversion-related and 
      reward-related processing based on results obtained from this study.
FAU - Nakao, Takashi
AU  - Nakao T
AD  - Department of Psychology, Graduate School of Education, Hiroshima University 
      Hiroshima, Japan.
FAU - Matsumoto, Tomoya
AU  - Matsumoto T
AD  - Department of Psychiatry and Neurosciences, Institute of Biomedical and Health 
      Sciences, Hiroshima University Hiroshima, Japan.
FAU - Shimizu, Daisuke
AU  - Shimizu D
AD  - Faculty of Medicine, Hiroshima University Hiroshima, Japan.
FAU - Morita, Machiko
AU  - Morita M
AD  - Faculty of Medicine, Hiroshima University Hiroshima, Japan.
FAU - Yoshimura, Shinpei
AU  - Yoshimura S
AD  - Department of Psychology, Faculty of Psychology, Otemon Gakuin University Osaka, 
      Japan.
FAU - Northoff, Georg
AU  - Northoff G
AD  - Institute of Mental Health Research, University of Ottawa Ottawa, ON, Canada.
FAU - Morinobu, Shigeru
AU  - Morinobu S
AD  - Department of Psychiatry and Neurosciences, Institute of Biomedical and Health 
      Sciences, Hiroshima University Hiroshima, Japan ; Department of Neuropsychiatry, 
      Kochi University Kochi, Japan.
FAU - Okamoto, Yasumasa
AU  - Okamoto Y
AD  - Department of Psychiatry and Neurosciences, Institute of Biomedical and Health 
      Sciences, Hiroshima University Hiroshima, Japan.
FAU - Yamawaki, Shigeto
AU  - Yamawaki S
AD  - Department of Psychiatry and Neurosciences, Institute of Biomedical and Health 
      Sciences, Hiroshima University Hiroshima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20131217
PL  - Switzerland
TA  - Front Syst Neurosci
JT  - Frontiers in systems neuroscience
JID - 101477946
PMC - PMC3865766
OTO - NOTNLM
OT  - aversion
OT  - harm avoidance
OT  - low-frequency fluctuations
OT  - medial prefrontal cortex (MPFC)
OT  - novelty seeking
OT  - personality
OT  - resting state
OT  - reward
EDAT- 2014/01/02 06:00
MHDA- 2014/01/02 06:01
PMCR- 2013/01/01
CRDT- 2014/01/02 06:00
PHST- 2013/09/30 00:00 [received]
PHST- 2013/12/02 00:00 [accepted]
PHST- 2014/01/02 06:00 [entrez]
PHST- 2014/01/02 06:00 [pubmed]
PHST- 2014/01/02 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fnsys.2013.00115 [doi]
PST - epublish
SO  - Front Syst Neurosci. 2013 Dec 17;7:115. doi: 10.3389/fnsys.2013.00115. 
      eCollection 2013.