PMID- 24381588
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140101
LR  - 20211021
IS  - 1687-6334 (Print)
IS  - 1687-6342 (Electronic)
IS  - 1687-6334 (Linking)
VI  - 2013
DP  - 2013
TI  - Dehydroepiandrosterone stimulates nerve growth factor and brain derived 
      neurotrophic factor in cortical neurons.
PG  - 506191
LID - 10.1155/2013/506191 [doi]
LID - 506191
AB  - Due to the increasing cases of neurodegenerative diseases in recent years, the 
      eventual goal of nerve repair is very important. One approach for achieving a 
      neuronal cell induction is by regenerative pharmacology. Nerve growth factor 
      (NGF) and brain derived neurotrophic factor (BDNF) are neurotrophins that play 
      roles in neuronal development, differentiation, and protection. On the other 
      hand, dehydroepiandrosterone (DHEA) is a neurosteroid which has multiple actions 
      in the nervous system. DHEA could be an important agent in regenerative 
      pharmacology for neuronal differentiation during tissue regeneration. In this 
      study, we investigated the possible role of DHEA to modulate NGF and BDNF 
      production. The in vivo level of neurotrophins expression was demonstrated by 
      ELISA in rat harvested brain cortex. Also neurotrophins expression after DHEA 
      treatment was revealed by the increased neurite extension, immunostaining, and 
      BrdU labeling in rats. Anti-NGF and anti-BDNF antibodies were used as suppressive 
      agents on neurogenesis. The results showed that NGF and BDNF are overproduced 
      after DHEA treatment but there is not any overexpression for NT-3 and NT-4. Also 
      DHEA increased neurite extension and neural cell proliferation significantly. 
      Overall, DHEA might induce NGF and BDNF neurotrophins overproduction in cortical 
      neurons which promotes neural cell protection, survival, and proliferation.
FAU - Rahmani, Anahita
AU  - Rahmani A
AD  - Stem Cell and Tissue Engineering Department, Research Center for Science and 
      Technology in Medicine (RCSTiM), Tehran University of Medical Sciences, Tehran 
      19988-96953, Iran.
FAU - Shoae-Hassani, Alireza
AU  - Shoae-Hassani A
AD  - Stem Cell and Tissue Engineering Department, Research Center for Science and 
      Technology in Medicine (RCSTiM), Tehran University of Medical Sciences, Tehran 
      19988-96953, Iran ; Applied Cell Sciences Department, School of Advanced 
      Technologies in Medicine, Tehran University of Medical Sciences, Tehran 
      19988-96953, Iran.
FAU - Keyhanvar, Peyman
AU  - Keyhanvar P
AD  - Rajaie Cardiovascular, Medical and Research Centre, Iran University of Medical 
      Sciences, Tehran 19969-14151, Iran.
FAU - Kheradmand, Danial
AU  - Kheradmand D
AD  - Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad 91779-48564, 
      Iran.
FAU - Darbandi-Azar, Amir
AU  - Darbandi-Azar A
AD  - Rajaie Cardiovascular, Medical and Research Centre, Iran University of Medical 
      Sciences, Tehran 19969-14151, Iran.
LA  - eng
PT  - Journal Article
DEP - 20131204
PL  - United States
TA  - Adv Pharmacol Sci
JT  - Advances in pharmacological sciences
JID - 101537654
PMC - PMC3867952
EDAT- 2014/01/02 06:00
MHDA- 2014/01/02 06:01
PMCR- 2013/12/04
CRDT- 2014/01/02 06:00
PHST- 2013/08/13 00:00 [received]
PHST- 2013/10/15 00:00 [revised]
PHST- 2013/10/15 00:00 [accepted]
PHST- 2014/01/02 06:00 [entrez]
PHST- 2014/01/02 06:00 [pubmed]
PHST- 2014/01/02 06:01 [medline]
PHST- 2013/12/04 00:00 [pmc-release]
AID - 10.1155/2013/506191 [doi]
PST - ppublish
SO  - Adv Pharmacol Sci. 2013;2013:506191. doi: 10.1155/2013/506191. Epub 2013 Dec 4.