PMID- 24381715
OWN - NLM
STAT- MEDLINE
DCOM- 20140715
LR  - 20211021
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2013
DP  - 2013
TI  - Magnolia extract (BL153) ameliorates kidney damage in a high fat diet-induced 
      obesity mouse model.
PG  - 367040
LID - 10.1155/2013/367040 [doi]
LID - 367040
AB  - Accumulating evidence demonstrated that obesity is a risk factor for renal 
      structural and functional changes, leading to the end-stage renal disease which 
      imposes a heavy economic burden on the community. However, no effective 
      therapeutic method for obesity-associated kidney disease is available. In the 
      present study, we explored the therapeutic potential of a magnolia extract 
      (BL153) for treating obesity-associated kidney damage in a high fat diet- (HFD-) 
      induced mouse model. The results showed that inflammation markers (tumor necrosis 
      factor- alpha and plasminogen activator inhibitor-1) and oxidative stress markers 
      (3-nitrotyrosine and 4-hydroxy-2-nonenal) were all significantly increased in the 
      kidney of HFD-fed mice compared to mice fed with a low fat diet (LFD). 
      Additionally, proteinuria and renal structure changes in HFD-fed mice were much 
      more severe than that in LFD-fed mice. However, all these alterations were 
      attenuated by BL153 treatment, accompanied by upregulation of peroxisome 
      proliferator-activated receptor- gamma coactivator-1 alpha (PGC-1 alpha ) and hexokinase II 
      (HK II) expression in the kidney. The present study indicates that BL153 
      administration may be a novel approach for renoprotection in obese individuals by 
      antiinflammation and anti-oxidative stress most likely via upregulation of PGC-1 
      alpha and HK II signal in the kidney.
FAU - Cui, Wenpeng
AU  - Cui W
AD  - The Second Hospital of Jilin University, Changchun 130041, China ; The Kosair 
      Children's Hospital Research Institute, Department of Pediatrics of the 
      University of Louisville, Louisville, KY 20202, USA.
FAU - Wang, Yangwei
AU  - Wang Y
AD  - The Second Hospital of Jilin University, Changchun 130041, China ; The Kosair 
      Children's Hospital Research Institute, Department of Pediatrics of the 
      University of Louisville, Louisville, KY 20202, USA.
FAU - Chen, Qiang
AU  - Chen Q
AD  - The Kosair Children's Hospital Research Institute, Department of Pediatrics of 
      the University of Louisville, Louisville, KY 20202, USA ; School of Public 
      Health, Jilin University, Changchun 130021, China.
FAU - Sun, Weixia
AU  - Sun W
AD  - The Kosair Children's Hospital Research Institute, Department of Pediatrics of 
      the University of Louisville, Louisville, KY 20202, USA ; The First Hospital of 
      Jilin University, Changchun 130021, China.
FAU - Cai, Lu
AU  - Cai L
AD  - The Kosair Children's Hospital Research Institute, Department of Pediatrics of 
      the University of Louisville, Louisville, KY 20202, USA.
FAU - Tan, Yi
AU  - Tan Y
AD  - The Kosair Children's Hospital Research Institute, Department of Pediatrics of 
      the University of Louisville, Louisville, KY 20202, USA.
FAU - Kim, Ki-Soo
AU  - Kim KS
AD  - Bioland Biotec Co., Ltd., Zhangjiang Modern Medical Device Park, Pudong, Shanghai 
      201201, China.
FAU - Kim, Ki Ho
AU  - Kim KH
AD  - Bioland R&D Center, 59 Songjeongni 2-gil, Byeongcheon, Dongnam, Cheonan, Chungnam 
      330-863, Republic of Korea.
FAU - Kim, Young Heui
AU  - Kim YH
AD  - Bioland R&D Center, 59 Songjeongni 2-gil, Byeongcheon, Dongnam, Cheonan, Chungnam 
      330-863, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131128
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (BL153 extract)
RN  - 0 (PPAR gamma)
RN  - 0 (Plant Extracts)
RN  - 0 (Protective Agents)
RN  - EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone))
RN  - EC 1.6.5.2 (Nqo1 protein, mouse)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Animals
MH  - Diet, High-Fat
MH  - Disease Models, Animal
MH  - Hexokinase/metabolism
MH  - Inflammation/pathology
MH  - Kidney/drug effects/enzymology/*pathology/physiopathology
MH  - Kidney Function Tests
MH  - Magnolia/*chemistry
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Biological
MH  - NAD(P)H Dehydrogenase (Quinone)/metabolism
MH  - Obesity/enzymology/*pathology/physiopathology
MH  - Oxidative Stress/drug effects
MH  - PPAR gamma/metabolism
MH  - Plant Extracts/*pharmacology
MH  - Protective Agents/pharmacology/therapeutic use
MH  - Up-Regulation/drug effects
PMC - PMC3863519
EDAT- 2014/01/02 06:00
MHDA- 2014/07/16 06:00
PMCR- 2013/11/28
CRDT- 2014/01/02 06:00
PHST- 2013/09/19 00:00 [received]
PHST- 2013/10/31 00:00 [revised]
PHST- 2013/11/06 00:00 [accepted]
PHST- 2014/01/02 06:00 [entrez]
PHST- 2014/01/02 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
PHST- 2013/11/28 00:00 [pmc-release]
AID - 10.1155/2013/367040 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2013;2013:367040. doi: 10.1155/2013/367040. Epub 2013 Nov 
      28.