PMID- 24381879
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140101
LR  - 20211021
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 17
IP  - 6
DP  - 2013 Nov
TI  - Assessment of serum levels of soluble CD40L in Egyptian children and adolescents 
      with type 1 diabetes mellitus: Relationship to microalbuminuria and glycemic 
      control.
PG  - 1024-9
LID - 10.4103/2230-8210.122617 [doi]
AB  - CONTEXT: Soluble CD40 ligand (sCD40L) is known to be elevated in different 
      clinical situations including hypercholesterolemia, acute coronary syndromes, and 
      type 2 diabetes mellitus (T2DM), Data about the relationship between type 1 
      diabetes mellitus (T1DM) and sCD40L is limited. In addition, the potential role 
      ofsCD40Lin the pathogenesis of vascular complications in children and adolescents 
      with T1DM is to be clarified. Hence, the study aimed at assessment of sCD40L 
      levels in children and adolescents with T1DM and correlation of these levels with 
      glycemic control and microalbuminuria. SETTINGS AND DESIGN: Cross-sectional 
      controlled study. MATERIALS AND METHODS: The study was performed in the Pediatric 
      Endocrinology and Diabetes Unit, Assuit University Children Hospital, Assiut, 
      Egypt. It included 70 children and adolescents with T1DM (mean age 14. 76 +/- 2.21 
      years). Cases were further subdivided into 43 cases with normoalbuminuria and 27 
      cases with microalbuminuria according to presence or absence or microalbuminuria 
      in fresh urine samples. Twentyfive healthy subjects, age- and sex-matched were 
      included as control group (mean age = 13.62 +/- 2.11 years). Studied cases were 
      subjected to medical history, clinical examination, and laboratory assessment of 
      fasting blood glucose (FBG), lipid profile, glycosylated hemoglobin (HbA1c), and 
      sCD40L were performed. RESULTS: Mean HbA1c and sCD40L were significantly higher 
      in diabetic children (n = 70) compared to control (n = 25) (P < 0.001 for each). 
      Mean HbA1c and sCD40L levels were significantly higher in microalbuminuric cases 
      (n = 27) compared to normoalbuminuric cases (n = 43) (P < 0.05 and <0.01, 
      respectively). We also observed a significant positive correlation between sCD40L 
      levels and the age, diabetes duration, HbA1c, and urinary albumin creatinine 
      ratio. CONCLUSIONS: The high serum sCD40L levels in children and adolescents with 
      T1DM particularly in those with microalbminuria and its positive correlation with 
      diabetes duration, urinary albumin excretion, and glycemic control may reflect 
      the role of sCD40L in diabetic vasculopathy in the pediatric age group. Moreover, 
      measurement of serum sCD40L levels in poorly controlled patients would help to 
      identify those at high risk of developing nephropathy.
FAU - Metwalley, Kotb Abbass
AU  - Metwalley KA
AD  - Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
FAU - Farghaly, Hekma Saad
AU  - Farghaly HS
AD  - Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
FAU - El-Saied, Abdel-Rahman Abdel-Hamed
AU  - El-Saied AR
AD  - Department of Clinical Pathology, Faculty of Medicine, South Valley University, 
      Qena, Egypt.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC3872680
OTO - NOTNLM
OT  - Glycemic control
OT  - microalbuminuria
OT  - sCD40L
OT  - type 1 diabetes mellitus
COIS- Conflict of Interest: None declared
EDAT- 2014/01/02 06:00
MHDA- 2014/01/02 06:01
PMCR- 2013/11/01
CRDT- 2014/01/02 06:00
PHST- 2014/01/02 06:00 [entrez]
PHST- 2014/01/02 06:00 [pubmed]
PHST- 2014/01/02 06:01 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - IJEM-17-1024 [pii]
AID - 10.4103/2230-8210.122617 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2013 Nov;17(6):1024-9. doi: 10.4103/2230-8210.122617.