PMID- 24383379
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20161128
IS  - 0966-8519 (Print)
IS  - 0966-8519 (Linking)
VI  - 22
IP  - 5
DP  - 2013 Sep
TI  - Is there an alternative explanation to post-myocardial infarction emergence of 
      mitral regurgitation? A CMR-LGE observational study.
PG  - 669-74
AB  - BACKGROUND AND AIM OF THE STUDY: Post-myocardial infarction (MI) mitral 
      regurgitation (MR) is thought to be due to a passive, rather than active, 
      remodeling of the mitral valve apparatus and its relationship with other cardiac 
      structures that contribute to MR. Standard contrast-enhanced magnetic resonance 
      (CMR) late gadolinium enhancement (LGE) may be sensitive to non-myocardial 
      pathology involving the mitral valve leaflets. It was hypothesized that the 
      presence of mitral valve enhancement (MVE) on LGE imaging in post-MI patients 
      would be associated with an increased incidence of MR. METHODS: The presence or 
      absence of MVE was noted in patients presenting for CMR with MI and non-MI 
      indications requiring LGE. A chi-square analysis was performed for non-contiguous 
      variables; SPSS (Chicago) software was utilized for the statistical analysis. 
      RESULTS: Eighty-seven patients (54 males, 33 females) underwent LGE-CMR studies 
      utilizing a 1.5 T GE scanner with MultiHance gadolinium contrast administration. 
      LGE+ (present) was noted in 68 patients, and LGE- (absent) in 19 patients. 
      Post-MI patterns of LGE+ were noted in 51 patients and LGE-in 36 patients; MVE+ 
      was noted in 39 patients and MVE- in 48; and MR+ was present in 67 patients and 
      absent (MR-) in 20 patients. MVE was observed chiefly in post-MI patients (33/51; 
      65%) and infrequently in non-post-MI patients (6/36; 17%; chi2 = 17.8, p < 0.001, 
      power = 0.995). Further, MR was present more frequently in patients with MVE 
      (36/39; 92%) compared to patients without MVE (31/48; 65%; chi2 = 7.8, p = 0.005, 
      power = 0.814). CONCLUSION: MVE is present in a large number of post-MI patients 
      but rarely in non-post-MI patients. Post-MI patients with, rather than without, 
      MVE are far more likely to have MR. These observations suggest a specific but 
      as-yet unknown reactive process that may contribute to mitral leaflet remodeling 
      in post-MI patients, potentially contributing to an increased incidence of MR in 
      post-MI patients.
FAU - Bogabathina, Hari
AU  - Bogabathina H
AD  - Department of Cardiovascular Magnetic Resonance, Gerald McGinnis Cardiovascular 
      Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA.
FAU - Doyle, Mark
AU  - Doyle M
AD  - Department of Cardiovascular Magnetic Resonance, Gerald McGinnis Cardiovascular 
      Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA.
FAU - Williams, Ronald
AU  - Williams R
AD  - Department of Cardiovascular Magnetic Resonance, Gerald McGinnis Cardiovascular 
      Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA.
FAU - Yamrozik, June
AU  - Yamrozik J
AD  - Department of Cardiovascular Magnetic Resonance, Gerald McGinnis Cardiovascular 
      Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA.
FAU - Vido, Diane
AU  - Vido D
AD  - Department of Cardiovascular Magnetic Resonance, Gerald McGinnis Cardiovascular 
      Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA.
FAU - Biederman, Robert W W
AU  - Biederman RW
AD  - Department of Cardiovascular Magnetic Resonance, Gerald McGinnis Cardiovascular 
      Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Heart Valve Dis
JT  - The Journal of heart valve disease
JID - 9312096
SB  - IM
MH  - Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Mitral Valve/diagnostic imaging/*pathology
MH  - Mitral Valve Insufficiency/diagnosis/epidemiology/*etiology
MH  - Myocardial Infarction/*complications/diagnosis
MH  - Prognosis
MH  - Retrospective Studies
MH  - Ultrasonography
MH  - United States/epidemiology
EDAT- 2014/01/05 06:00
MHDA- 2014/01/24 06:00
CRDT- 2014/01/04 06:00
PHST- 2014/01/04 06:00 [entrez]
PHST- 2014/01/05 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
PST - ppublish
SO  - J Heart Valve Dis. 2013 Sep;22(5):669-74.