PMID- 24383685
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140107
LR  - 20161020
IS  - 1439-7595 (Print)
IS  - 1439-7595 (Linking)
VI  - 11
IP  - 2
DP  - 2001 Jun
TI  - Molecular and cellular analyses of HLA class II-associated susceptibility to 
      autoimmune diseases in the Japanese population.
PG  - 103-12
LID - 10.3109/s101650170020 [doi]
AB  - Abstract It is well known that individuals who are positive for particular HLA 
      class II alleles show a high risk of developing autoimmune diseases. HLA class II 
      molecules expressed on antigen-presenting cells present antigenic peptides to 
      CD4(+) T cells. Their extensive polymorphism affects the structures of peptides 
      bound to HLA class II molecules to create individual differences in immune 
      responses to antigenic peptides. In order to gain a better understanding of 
      mechanisms of the association between HLA class II alleles and susceptibility to 
      autoimmune diseases, it is important to identify self-peptides presented by 
      disease-susceptible HLA class II molecules and triggering disease-causative T 
      cells. Many of the autoimmune diseases are observed in all ethnic groups, whereas 
      the incidence of diseases, clinical manifestations and disease-susceptible HLA 
      class II alleles are different among various ethnic groups for some autoimmune 
      diseases. These phenomena suggest that differences in autoimmune self-peptide(s) 
      in the context of disease-susceptible HLA class II molecules may cause these 
      differences. Therefore, comparisons among disease-susceptible HLA class II 
      alleles, autoantigenic peptides, and clinical manifestations of autoimmune 
      diseases in different ethnic groups would be helpful in elucidating the 
      pathogenesis of the diseases. In this review, we describe our recent findings on 
      (1) the uniqueness of both clinical manifestations and the HLA-linked genetic 
      background of Asian-type (opticospinal form) multiple sclerosis, (2) the 
      characteristics of glutamic acid decarboxylase 65 (GAD65) or beta2-glycoprotein I 
      (beta2-GPI) autoreactive T cells in Japanese patients with insulin-dependent 
      diabetes mellitus (IDDM) or anti-beta2-GPI antibody-associated autoimmunity, 
      respectively, and (3) the generation of an efficient delivery system of peptides 
      to the HLA class II-restricted antigen presentation path-way by utilizing a class 
      II-associated invariant chain peptide (CLIP)-substituted invariant chain, which 
      may be applicable to an evaluation of the "molecular mimicry hypothesis" for the 
      activation of autoreactive T cells.
FAU - Nishimura, Y
AU  - Nishimura Y
AD  - Division of Immunogenetics, Department of Neuroscience and Immunology, Kumamoto 
      University Graduate School of Medical Sciences , 2-2-1 Honjo, Kumamoto 860-0811 , 
      Japan.
FAU - Ito, H
AU  - Ito H
FAU - Fujii, S
AU  - Fujii S
FAU - Tabata, H
AU  - Tabata H
FAU - Tokano, Y
AU  - Tokano Y
FAU - Chen, Y Z
AU  - Chen YZ
FAU - Matsuda, I
AU  - Matsuda I
FAU - Mitsuya, H
AU  - Mitsuya H
FAU - Kira, J
AU  - Kira J
FAU - Hashimoto, H
AU  - Hashimoto H
FAU - Senju, S
AU  - Senju S
FAU - Matsushita, S
AU  - Matsushita S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
EDAT- 2001/06/01 00:00
MHDA- 2001/06/01 00:01
CRDT- 2014/01/04 06:00
PHST- 2014/01/04 06:00 [entrez]
PHST- 2001/06/01 00:00 [pubmed]
PHST- 2001/06/01 00:01 [medline]
AID - 10.3109/s101650170020 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2001 Jun;11(2):103-12. doi: 10.3109/s101650170020.