PMID- 24383686
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140107
LR  - 20161020
IS  - 1439-7595 (Print)
IS  - 1439-7595 (Linking)
VI  - 11
IP  - 2
DP  - 2001 Jun
TI  - Antibody specificity and related clinical features in antiphospholipid syndrome.
PG  - 113-20
LID - 10.3109/s101650170021 [doi]
AB  - Abstract The concept of antiphospholipid syndrome (APS) has been widely accepted. 
      Antiphospholipid antibodies originally included anticardiolipin antibodies and 
      lupus anticoagulants. However, recent advances have shown that most pathogenic 
      antiphospholipid antibodies are directed to phospholipid binding proteins such as 
      beta2-glycoprotein I (beta2-GPI) and prothrombin. Other candidates for antigens of 
      so-called antiphospholipid antibodies are protein C, protein S, factor V, factor 
      X, annexin V, high and low molecular weight kininogens, and complex with beta2-GPI 
      and oxidized low-density lipoprotein (LDL). These autoantibodies directed to 
      different phospholipid binding proteins are present in the blood stream, and 
      contribute to triggering procoagulant effects on endothelial cells and platelets, 
      leading to thrombosis. The heterogeneity of these antiphospholipid antibodies 
      appears to explain various clinical manifestations in patients with APS. The 
      preliminary classification criteria for definite APS and a general management 
      policy have been proposed, although successful treatment of patients with 
      antiphospholipid antibodies have only been shown by retrospective studies. 
      Further prospective investigations are required to confirm the diagnostic and 
      therapeutic criteria for patients with APS.
FAU - Kaburaki, J
AU  - Kaburaki J
AD  - Department of Internal Medicine, Tokyo Electric Power Company (TEPCO) Hospital , 
      9-2 Shinanomachi, Shinjuku-ku, Tokyo 160-0016 , Japan.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
EDAT- 2001/06/01 00:00
MHDA- 2001/06/01 00:01
CRDT- 2014/01/04 06:00
PHST- 2014/01/04 06:00 [entrez]
PHST- 2001/06/01 00:00 [pubmed]
PHST- 2001/06/01 00:01 [medline]
AID - 10.3109/s101650170021 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2001 Jun;11(2):113-20. doi: 10.3109/s101650170021.