PMID- 24384240
OWN - NLM
STAT- MEDLINE
DCOM- 20140915
LR  - 20140203
IS  - 1873-2941 (Electronic)
IS  - 0009-3084 (Linking)
VI  - 178
DP  - 2014 Feb
TI  - Comparison of plasma and erythrocyte membrane fatty acid compositions in patients 
      with end-stage renal disease and type 2 diabetes mellitus.
PG  - 11-7
LID - S0009-3084(13)00183-7 [pii]
LID - 10.1016/j.chemphyslip.2013.12.011 [doi]
AB  - BACKGROUND: In this study, we aimed to compare the serum lipid profile and fatty 
      acid (FA) compositions of erythrocyte membrane (EM) and plasma in three different 
      patient groups (group 1: type 2 diabetes mellitus (T2DM)+end-stage renal disease 
      (ESRD), group 2: ESRD, group 4: T2DM) and healthy controls (group 3) 
      simultaneously. METHODS: 40 ESRD patients treated with hemodialysis (HD) in 
      Gulhane School of Medicine (20 with T2DM) and 32 controls (17 with T2DM, 15 
      healthy controls) were included in the study. Plasma and EM FA concentrations 
      were measured by gas chromatography-flame ionization detector (GC-FID). RESULTS: 
      Plasma and EM palmitic acid (PA) and stearic acid (SA) levels were significantly 
      higher in T2DM patients compared to controls (p=0.040 and p=0.002 for plasma, 
      p=0.001 and p=0.010 for EM, respectively). EM docosahexaenoic acid (DHA) levels 
      were also significantly lower in patients with ESRD+T2DM and ESRD compared to 
      controls (p=0.004 and p=0.037, respectively). CONCLUSIONS: Patients with insulin 
      resistance display a pattern of high long chain saturated FAs (PA, SA and 
      arachidic acids). However, while there are no recognized standards for normal EM 
      DHA content, decreased levels of EM DHA in ESRD patient groups (groups 1 and 2) 
      suggest that there may be reduced endogenous synthesis of DHA in HD subjects, due 
      to the decreased functionality of desaturase and elongase enzymes. Because 
      membrane PUFA content affects membrane fluidity and cell signaling, these 
      findings are worthy of further investigation.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Sertoglu, Erdim
AU  - Sertoglu E
AD  - Ankara Mevki Military Hospital, Anittepe Dispensary, Ankara, Turkey. Electronic 
      address: erdimsertoglu@gmail.com.
FAU - Kurt, Ismail
AU  - Kurt I
AD  - Gulhane School of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
FAU - Tapan, Serkan
AU  - Tapan S
AD  - Gulhane School of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
FAU - Uyanik, Metin
AU  - Uyanik M
AD  - Gulhane School of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
FAU - Serdar, Muhittin A
AU  - Serdar MA
AD  - Acibadem University School of Medicine, Department of Medical Biochemistry, 
      Istanbul, Turkey.
FAU - Kayadibi, Huseyin
AU  - Kayadibi H
AD  - Adana Military Hospital, Department of Medical Biochemistry, Adana, Turkey.
FAU - El-Fawaeir, Saad
AU  - El-Fawaeir S
AD  - Gulhane School of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20131231
PL  - Ireland
TA  - Chem Phys Lipids
JT  - Chemistry and physics of lipids
JID - 0067206
RN  - 0 (Fatty Acids)
RN  - 0 (Stearic Acids)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 2V16EO95H1 (Palmitic Acid)
RN  - 4ELV7Z65AP (stearic acid)
SB  - IM
MH  - Adult
MH  - Cell Membrane/*chemistry
MH  - Diabetes Mellitus, Type 2/*metabolism/pathology
MH  - Docosahexaenoic Acids/metabolism
MH  - Erythrocyte Membrane/*chemistry
MH  - Fatty Acids/*metabolism
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Palmitic Acid/metabolism
MH  - Stearic Acids/metabolism
OTO - NOTNLM
OT  - End-stage renal disease
OT  - Erythrocyte membrane
OT  - Fatty acids
OT  - Plasma
OT  - Type 2 diabetes mellitus
EDAT- 2014/01/05 06:00
MHDA- 2014/09/16 06:00
CRDT- 2014/01/04 06:00
PHST- 2013/11/14 00:00 [received]
PHST- 2013/12/22 00:00 [revised]
PHST- 2013/12/23 00:00 [accepted]
PHST- 2014/01/04 06:00 [entrez]
PHST- 2014/01/05 06:00 [pubmed]
PHST- 2014/09/16 06:00 [medline]
AID - S0009-3084(13)00183-7 [pii]
AID - 10.1016/j.chemphyslip.2013.12.011 [doi]
PST - ppublish
SO  - Chem Phys Lipids. 2014 Feb;178:11-7. doi: 10.1016/j.chemphyslip.2013.12.011. Epub 
      2013 Dec 31.