PMID- 24384399
OWN - NLM
STAT- MEDLINE
DCOM- 20140928
LR  - 20211021
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 51
DP  - 2014 Mar
TI  - Patterns of intraspecific variability in the response to caloric restriction.
PG  - 28-37
LID - S0531-5565(13)00361-6 [pii]
LID - 10.1016/j.exger.2013.12.005 [doi]
AB  - Caloric restriction (CR) is cited as the most robust means of increasing lifespan 
      across a range of taxa, yet there is a high degree of variability in the response 
      to CR, both within and between species. To examine the intraspecific evolutionary 
      conservation of lifespan extension by CR, we tested the effects of chronic 
      caloric restriction (CCR) at multiple food levels and of intermittent fasting 
      (IF) in twelve isolates from the Brachionus plicatilis species complex of 
      monogonont rotifers. While CCR generally increased or did not change lifespan and 
      total fecundity, IF caused increased, unchanged, or decreased lifespan, depending 
      upon the isolate, and decreased total fecundity in all but one isolate. Lifespan 
      under ad libitum (AL) feeding varied among isolates and predicted the lifespan 
      response to CR: longer-lived isolates under AL were less likely to have a 
      significant increase in lifespan under CCR and were more likely to have a 
      significantly shortened lifespan under IF. Lifespan under AL conditions and the 
      response to CR were not correlated with hydroperiodicity of native habitat or 
      with time in culture. Lack of trade-off between lifespan and fecundity under CCR, 
      and differences in lifespan and fecundity under CCR and IF, even when average 
      food intake was similar, suggest that longevity changes are not always directly 
      determined by energy intake and that CCR and IF regimens extend lifespan through 
      diverse genetic mechanisms.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Gribble, Kristin E
AU  - Gribble KE
AD  - Marine Biological Laboratory, 7 MBL St., Woods Hole, MA 02543, USA.
FAU - Kaido, Oksana
AU  - Kaido O
AD  - Marine Biological Laboratory, 7 MBL St., Woods Hole, MA 02543, USA; Northeastern 
      University, 360 Huntington Ave, Boston, MA 02115, USA.
FAU - Jarvis, George
AU  - Jarvis G
AD  - Marine Biological Laboratory, 7 MBL St., Woods Hole, MA 02543, USA; Northeastern 
      University, 360 Huntington Ave, Boston, MA 02115, USA.
FAU - Mark Welch, David B
AU  - Mark Welch DB
AD  - Marine Biological Laboratory, 7 MBL St., Woods Hole, MA 02543, USA. Electronic 
      address: dmarkwelch@mbl.edu.
LA  - eng
GR  - R01 AG037960/AG/NIA NIH HHS/United States
GR  - R01 AG037960-01/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131231
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
SB  - IM
MH  - Animals
MH  - Caloric Restriction/methods
MH  - Ecosystem
MH  - Energy Intake/*physiology
MH  - Fasting/*physiology
MH  - Fertility/physiology
MH  - Longevity/*physiology
MH  - Rotifera
MH  - Species Specificity
PMC - PMC3936681
MID - NIHMS552034
OTO - NOTNLM
OT  - Caloric restriction
OT  - Evolution of aging
OT  - Intermittent fasting
OT  - Resource allocation
OT  - Rotifer
OT  - Trade-off
COIS- Conflict of interest The authors have no conflicts of interests.
EDAT- 2014/01/05 06:00
MHDA- 2014/10/01 06:00
PMCR- 2015/03/01
CRDT- 2014/01/04 06:00
PHST- 2013/07/23 00:00 [received]
PHST- 2013/12/10 00:00 [revised]
PHST- 2013/12/12 00:00 [accepted]
PHST- 2014/01/04 06:00 [entrez]
PHST- 2014/01/05 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - S0531-5565(13)00361-6 [pii]
AID - 10.1016/j.exger.2013.12.005 [doi]
PST - ppublish
SO  - Exp Gerontol. 2014 Mar;51:28-37. doi: 10.1016/j.exger.2013.12.005. Epub 2013 Dec 
      31.