PMID- 24384468
OWN - NLM
STAT- MEDLINE
DCOM- 20141208
LR  - 20171116
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 38
DP  - 2014 May
TI  - The different effects of LPS and poly I:C prenatal immune challenges on the 
      behavior, development and inflammatory responses in pregnant mice and their 
      offspring.
PG  - 77-90
LID - S0889-1591(13)00601-6 [pii]
LID - 10.1016/j.bbi.2013.12.016 [doi]
AB  - In recent years, in vivo animal models of prenatal infection have been developed 
      in an attempt to recreate behavioral and neuropathological features associated to 
      a number of neurological and neuropsychiatric disorders. However, these models 
      are still in their emerging phase and a better understanding of how these types 
      of infections relate to adult-onset of brain-related disorders is needed. Here, 
      we undertook an extensive behavioral characterization of both pregnant females 
      and their pups following late gestational exposure (from gestational days (GD) 
      15-17) to either lipopolysaccharide (LPS; 120mug/kg i.p.) or 
      polyinosinic:polycytidylic acid (poly I:C; 5mg/kg i.v.). We observed that both 
      LPS and poly I:C treatments produced anxiety-like behaviors in treated pregnant 
      females, although to a lesser extent with LPS. LPS injections, but not poly I:C, 
      led to reduced food intake and consequently decreased weight gain in pregnant 
      dams. In pups, poly I:C treatments triggered a delay in growth and sensorimotor 
      development, as evaluated by righting, geotaxis and grasping reflexes. At the 
      cellular level, both toxins induced an initial inflammatory response while only 
      LPS reduced the expression of brain cell markers in foetuses (GFAP and NeuN), 
      which was no longer observable at postnatal day (PnD) 10. Higher levels of IL-2, 
      IL-5 and IL-6 in plasma and an upregulation of the metabotropic receptor 5 
      (mGluR5) in foetal brains of 10-day-old offspring prenatally exposed to poly I:C 
      was also observed. Interestingly, the increased mGluR5 expression correlated with 
      impairments of the righting reflex. This study is the first to directly compare 
      reflex development following LPS and poly I:C prenatal immune challenges in mice 
      and sheds light onto the different patterns of behavior and pathology in dams and 
      their offspring.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Arsenault, Dany
AU  - Arsenault D
AD  - Centre de Recherche du CHU de Quebec (CHUQ), Axe Neurosciences, 2705, Boulevard 
      Laurier, Quebec, QC G1V 4G2, Canada.
FAU - St-Amour, Isabelle
AU  - St-Amour I
AD  - Centre de Recherche du CHU de Quebec (CHUQ), Axe Neurosciences, 2705, Boulevard 
      Laurier, Quebec, QC G1V 4G2, Canada.
FAU - Cisbani, Giulia
AU  - Cisbani G
AD  - Centre de Recherche du CHU de Quebec (CHUQ), Axe Neurosciences, 2705, Boulevard 
      Laurier, Quebec, QC G1V 4G2, Canada.
FAU - Rousseau, Louis-Simon
AU  - Rousseau LS
AD  - Centre de Recherche du CHU de Quebec (CHUQ), Axe Neurosciences, 2705, Boulevard 
      Laurier, Quebec, QC G1V 4G2, Canada.
FAU - Cicchetti, Francesca
AU  - Cicchetti F
AD  - Centre de Recherche du CHU de Quebec (CHUQ), Axe Neurosciences, 2705, Boulevard 
      Laurier, Quebec, QC G1V 4G2, Canada; Departement de Psychiatrie et Neurosciences, 
      Universite Laval, Quebec, QC G1K 7P4, Canada. Electronic address: 
      Francesca.Cicchetti@crchul.ulaval.ca.
LA  - eng
GR  - 1R01MH091684-01/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131230
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Animals
MH  - Anxiety/*immunology
MH  - Brain/metabolism
MH  - Cytokines/blood
MH  - Female
MH  - Inflammation/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Poly I-C/pharmacology
MH  - Pregnancy
MH  - Pregnancy Complications/*immunology
MH  - Prenatal Exposure Delayed Effects/*immunology/metabolism/physiopathology
OTO - NOTNLM
OT  - Behavior
OT  - Cytokines
OT  - Development
OT  - Immune response
OT  - Inflammation
OT  - mGluR5
EDAT- 2014/01/05 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/04 06:00
PHST- 2013/10/25 00:00 [received]
PHST- 2013/11/30 00:00 [revised]
PHST- 2013/12/20 00:00 [accepted]
PHST- 2014/01/04 06:00 [entrez]
PHST- 2014/01/05 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0889-1591(13)00601-6 [pii]
AID - 10.1016/j.bbi.2013.12.016 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2014 May;38:77-90. doi: 10.1016/j.bbi.2013.12.016. Epub 2013 
      Dec 30.