PMID- 24384800
OWN - NLM
STAT- MEDLINE
DCOM- 20141204
LR  - 20211021
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 252
IP  - 7
DP  - 2014 Jul
TI  - Spectral-domain optical coherence tomography evaluation of vitreoretinal 
      adhesions in idiopathic epiretinal membranes.
PG  - 1041-7
LID - 10.1007/s00417-013-2546-6 [doi]
AB  - BACKGROUND: Vitreoretinal adhesions play a key role in the vector forces exerted 
      on the vitreoretinal interface, leading to tractional retina deformation and 
      macular hole formation. The aim of this study was to identify the presence of 
      vitreopapillary and vitreofoveal adhesions in idiopathic epiretinal membranes 
      (ERMs) with spectral-domain optical coherence tomography (SD-OCT) and to evaluate 
      their influence on the vitreoretinal interface. METHODS: Sixty-five eyes (65 
      patients) with idiopathic ERM and 64 healthy eyes (64 patients) underwent SD-OCT 
      analysis. We studied vitreopapillary and vitreofoveal adhesion prevalence in eyes 
      with idiopathic ERM using different SD-OCT patterns ("adherent" or "tractional"). 
      We analyzed their influence on central foveal thickness (CFT), on retinal nerve 
      fiber layer (RNFL) thickness, and on morphological modifications (foveal 
      depression profile and inner/outer photoreceptor junction). RESULTS: 
      Vitreopapillary adhesion was present in 51.6 % of normal eyes and in 24.6 % of 
      eyes with idiopathic ERM, while vitreofoveal adhesion was found in 14.1 % of 
      normal eyes and in 15.4 % of eyes with ERM. Vitreopapillary adhesion prevalence 
      was significantly higher in the tractional ERM subgroup (p = 0.01), than in the 
      adherent ERM subgroup. Both adhesions had no influence on CFT, RNFL thickness, or 
      inner segment/outer segment junction status. CONCLUSIONS: Our study suggests that 
      vitreoretinal adhesions may influence the pathogenesis and course of idiopathic 
      ERM. The absence of vitreopapillary adhesion in the adherent type, and its 
      presence in the tractional type, seems to play a key role in ERM 
      characterization.
FAU - Pierro, Luisa
AU  - Pierro L
AD  - Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific 
      Institute, Via Olgettina, 60, 20132, Milan, Italy, pierro.luisa@hsr.it.
FAU - Gagliardi, Marco
AU  - Gagliardi M
FAU - Giatsidis, Silvia
AU  - Giatsidis S
FAU - Iuliano, Lorenzo
AU  - Iuliano L
FAU - Berchicci, Luigi
AU  - Berchicci L
FAU - Battaglia Parodi, Maurizio
AU  - Battaglia Parodi M
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20140103
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Cross-Sectional Studies
MH  - Epiretinal Membrane/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Microscopy, Acoustic
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Ophthalmoscopy
MH  - Prevalence
MH  - Retinal Diseases/*diagnosis
MH  - Retinal Ganglion Cells/pathology
MH  - Tissue Adhesions/diagnosis
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Vitreous Body/*pathology
EDAT- 2014/01/05 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/04 06:00
PHST- 2013/04/22 00:00 [received]
PHST- 2013/12/02 00:00 [accepted]
PHST- 2013/10/14 00:00 [revised]
PHST- 2014/01/04 06:00 [entrez]
PHST- 2014/01/05 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1007/s00417-013-2546-6 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2014 Jul;252(7):1041-7. doi: 
      10.1007/s00417-013-2546-6. Epub 2014 Jan 3.