PMID- 24385823 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140624 LR - 20211021 IS - 1300-7777 (Print) IS - 1308-5263 (Electronic) IS - 1300-7777 (Linking) VI - 30 IP - 4 DP - 2013 Dec TI - Strategies in haploidentical stem cell transplantation in adults. PG - 342-50 LID - 10.4274/Tjh.2013.0054 [doi] AB - Haploidentical related donors are alternative stem cell sources for patients without human leukocyte antigen (HLA)-matched related or unrelated donors. Immediate access to the donor, availability for patients with rare haplotypes, ease of stem cell procurement, and lack of a requirement for a physical cord blood bank or an extensive HLA database render this type of hematopoietic stem cell transplantation particularly attractive despite the high histoincompatibility barrier between the recipient and the haploidentical graft. In this review, we answer the following questions: 1) What are the current transplant strategies used to overcome the histoincompatibility barrier in haploidentical stem cell transplantation and their clinical results? 2) How should we choose the donor when there is more than one available haploidentical donor? 3) How does transplantation from haploidentical donors compare to that from umbilical cord blood? CONFLICT OF INTEREST: None declared. FAU - Bayraktar, Ulas D AU - Bayraktar UD AD - Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA ; Mercy Cancer Center, Medical Oncology, Hematology, Ardmore, OK, USA. FAU - Ciurea, Stefan O AU - Ciurea SO AD - Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. LA - eng PT - Journal Article PT - Review DEP - 20131205 PL - Turkey TA - Turk J Haematol JT - Turkish journal of haematology : official journal of Turkish Society of Haematology JID - 9606065 PMC - PMC3874970 OTO - NOTNLM OT - GVHD OT - HLA OT - Haploidentical stem cell transplantation EDAT- 2014/01/05 06:00 MHDA- 2014/01/05 06:01 PMCR- 2013/12/01 CRDT- 2014/01/04 06:00 PHST- 2013/02/13 00:00 [received] PHST- 2013/07/25 00:00 [accepted] PHST- 2014/01/04 06:00 [entrez] PHST- 2014/01/05 06:00 [pubmed] PHST- 2014/01/05 06:01 [medline] PHST- 2013/12/01 00:00 [pmc-release] AID - 1048 [pii] AID - 10.4274/Tjh.2013.0054 [doi] PST - ppublish SO - Turk J Haematol. 2013 Dec;30(4):342-50. doi: 10.4274/Tjh.2013.0054. Epub 2013 Dec 5.