PMID- 24386554
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140103
LR  - 20220311
IS  - 2005-3606 (Print)
IS  - 2005-5447 (Electronic)
IS  - 2005-3606 (Linking)
VI  - 6
IP  - 2
DP  - 2013 Nov
TI  - Histological experimental study on the effect of stem cell therapy on adriamycin 
      induced chemobrain.
PG  - 104-12
AB  - BACKGROUND AND OBJECTIVES: Negative consequences of chemotherapy on brain 
      function were suggested and were addressed in animal models as the clinical 
      phenomenon of chemobrain .It was postulated that adriamycin (ADR) induce changes 
      in behaviour and in brain morphology. Human umbilical cord mesenchymal stem cells 
      (HUCMSCs) could be induced to differentiate into neuron-like cells .The present 
      study aimed at investigating the possible therapeutic effect of HUCMSC therapy on 
      adriamycin induced chemobrain in rat. METHODS AND RESULTS: Twenty five female 
      albino rats were divided into control group, ADR group where rats were given 
      single intraperitoneal (IP) injection of 5 mg/kg ADR. The rats were sacrificed 
      two and four weeks following confirmation of brain damage. In stem cell therapy 
      group, rats were injected with HUCMSCs following confirmation of brain damage and 
      sacrificed two and four weeks after therapy. Brain sections were exposed to 
      histological, histochemical, immunohistochemical and morphometric studies. In ADR 
      group, multiple shrunken neurons exhibiting dark nuclei and surrounded by 
      vacuoles were seen .In response to SC therapy ,multiple normal pyramidal nerve 
      cells were noted. The area of shrunken nerve cells exhibiting dark nuclei, 
      Prussion blue and CD105 positive cells were significantly different in ADR group 
      in comparison to SC therapy group. CONCLUSIONS: ADR induced progressive duration 
      dependant cerebral degenerative changes. These changes were ameliorated following 
      cord blood human mesenchymal stem cell therapy. A reciprocal relation was 
      recorded between the extent of regeneration and the existence of undifferentiated 
      mesenchymal stem cells.
FAU - Zickri, Maha Baligh
AU  - Zickri MB
AD  - Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - El Aziz, Dalia Hussein Abd
AU  - El Aziz DH
AD  - Department of Histology, Faculty of Medicine, Beni-Suef University, Cairo, Egypt.
FAU - Metwally, Hala Gabr
AU  - Metwally HG
AD  - Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo, 
      Egypt.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Int J Stem Cells
JT  - International journal of stem cells
JID - 101497587
PMC - PMC3878203
OTO - NOTNLM
OT  - Adriamycin
OT  - Chemobrain
OT  - Cord blood
OT  - Mesenchymal stem cells
EDAT- 2014/01/05 06:00
MHDA- 2014/01/05 06:01
PMCR- 2013/12/01
CRDT- 2014/01/04 06:00
PHST- 2013/08/31 00:00 [accepted]
PHST- 2014/01/04 06:00 [entrez]
PHST- 2014/01/05 06:00 [pubmed]
PHST- 2014/01/05 06:01 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - ijsc-06-104 [pii]
AID - 10.15283/ijsc.2013.6.2.104 [doi]
PST - ppublish
SO  - Int J Stem Cells. 2013 Nov;6(2):104-12. doi: 10.15283/ijsc.2013.6.2.104.