PMID- 24386575
OWN - NLM
STAT- MEDLINE
DCOM- 20140722
LR  - 20240324
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2013
DP  - 2013
TI  - GluN3A: an NMDA receptor subunit with exquisite properties and functions.
PG  - 145387
LID - 10.1155/2013/145387 [doi]
LID - 145387
AB  - N-methyl-D-aspartate receptors (NMDAR) are pivotal for synaptic plasticity and 
      memory formation. Conventional NMDAR consist of heterotetrameric structures 
      composed of GluN1 and GluN2 subunits. A third subunit, GluN3, can also assemble 
      with NMDAR subunits giving a remarkable modification of their heteromeric 
      structure, forming a "nonconventional" NMDAR. As a consequence, the stoichiometry 
      and kinetic properties of the receptors are dramatically changed. Among the GluN3 
      family, the GluN3A subunit has been the focus of a large amount of studies during 
      recent years. These studies reveal that GluN3A is transiently expressed during 
      development and could play a role in the fine tuning of neuronal networks as well 
      as associated diseases. Moreover, GluN3A distribution outside the postsynaptic 
      densities, including perisynaptic astrocytes, places it at a strategic position 
      to play an important role in the interactions between neurons and glial cells. 
      This review highlights GluN3A properties and addresses its role in 
      neurophysiology and associated pathologies.
FAU - Kehoe, Laura A
AU  - Kehoe LA
AD  - Department of Neuroscience, University of Geneva, CMU, 1211 Geneve 4, Switzerland 
      ; Cellular Neurobiology, Departamento de Neurociencias, Centro de Investigacion 
      Medica Aplicada (CIMA), Universidad de Navarra, 31008 Pamplona, Spain.
FAU - Bernardinelli, Yann
AU  - Bernardinelli Y
AD  - Department of Neuroscience, University of Geneva, CMU, 1211 Geneve 4, 
      Switzerland.
FAU - Muller, Dominique
AU  - Muller D
AD  - Department of Neuroscience, University of Geneva, CMU, 1211 Geneve 4, 
      Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131209
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - 0 (GRIN3A protein, human)
RN  - 0 (GluN3A protein, mouse)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Astrocytes/physiology
MH  - Dendritic Spines/physiology
MH  - Gene Expression/physiology
MH  - Humans
MH  - Nerve Tissue Proteins/metabolism
MH  - Nervous System Diseases/genetics/physiopathology
MH  - Receptors, N-Methyl-D-Aspartate/biosynthesis/chemistry/genetics/*physiology
PMC - PMC3872238
EDAT- 2014/01/05 06:00
MHDA- 2014/07/23 06:00
PMCR- 2013/12/09
CRDT- 2014/01/04 06:00
PHST- 2013/09/20 00:00 [received]
PHST- 2013/11/12 00:00 [accepted]
PHST- 2014/01/04 06:00 [entrez]
PHST- 2014/01/05 06:00 [pubmed]
PHST- 2014/07/23 06:00 [medline]
PHST- 2013/12/09 00:00 [pmc-release]
AID - 10.1155/2013/145387 [doi]
PST - ppublish
SO  - Neural Plast. 2013;2013:145387. doi: 10.1155/2013/145387. Epub 2013 Dec 9.