PMID- 24387626
OWN - NLM
STAT- MEDLINE
DCOM- 20141021
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Jan 4
TI  - T1-mapping in the heart: accuracy and precision.
PG  - 2
LID - 10.1186/1532-429X-16-2 [doi]
AB  - The longitudinal relaxation time constant (T1) of the myocardium is altered in 
      various disease states due to increased water content or other changes to the 
      local molecular environment. Changes in both native T1 and T1 following 
      administration of gadolinium (Gd) based contrast agents are considered important 
      biomarkers and multiple methods have been suggested for quantifying myocardial T1 
      in vivo. Characterization of the native T1 of myocardial tissue may be used to 
      detect and assess various cardiomyopathies while measurement of T1 with 
      extracellular Gd based contrast agents provides additional information about the 
      extracellular volume (ECV) fraction. The latter is particularly valuable for more 
      diffuse diseases that are more challenging to detect using conventional late 
      gadolinium enhancement (LGE). Both T1 and ECV measures have been shown to have 
      important prognostic significance. T1-mapping has the potential to detect and 
      quantify diffuse fibrosis at an early stage provided that the measurements have 
      adequate reproducibility. Inversion recovery methods such as MOLLI have excellent 
      precision and are highly reproducible when using tightly controlled protocols. 
      The MOLLI method is widely available and is relatively mature. The accuracy of 
      inversion recovery techniques is affected significantly by magnetization transfer 
      (MT). Despite this, the estimate of apparent T1 using inversion recovery is a 
      sensitive measure, which has been demonstrated to be a useful tool in 
      characterizing tissue and discriminating disease. Saturation recovery methods 
      have the potential to provide a more accurate measurement of T1 that is less 
      sensitive to MT as well as other factors. Saturation recovery techniques are, 
      however, noisier and somewhat more artifact prone and have not demonstrated the 
      same level of reproducibility at this point in time.This review article focuses 
      on the technical aspects of key T1-mapping methods and imaging protocols and 
      describes their limitations including the factors that influence their accuracy, 
      precision, and reproducibility.
FAU - Kellman, Peter
AU  - Kellman P
AD  - National Heart, Lung, and Blood Institute, National Institutes of Health, 
      Bethesda, MD, USA. kellman@nih.gov.
FAU - Hansen, Michael S
AU  - Hansen MS
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140104
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
SB  - IM
MH  - Artifacts
MH  - Cardiomyopathies/*diagnosis/pathology/physiopathology
MH  - *Contrast Media
MH  - Fibrosis
MH  - Heart Rate
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - *Myocardial Contraction
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - *Ventricular Function
PMC - PMC3927683
EDAT- 2014/01/07 06:00
MHDA- 2014/10/22 06:00
PMCR- 2014/01/04
CRDT- 2014/01/07 06:00
PHST- 2013/11/28 00:00 [received]
PHST- 2013/12/24 00:00 [accepted]
PHST- 2014/01/07 06:00 [entrez]
PHST- 2014/01/07 06:00 [pubmed]
PHST- 2014/10/22 06:00 [medline]
PHST- 2014/01/04 00:00 [pmc-release]
AID - S1097-6647(23)00093-5 [pii]
AID - 1532-429X-16-2 [pii]
AID - 10.1186/1532-429X-16-2 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2014 Jan 4;16(1):2. doi: 10.1186/1532-429X-16-2.