PMID- 24387999 OWN - NLM STAT- MEDLINE DCOM- 20140923 LR - 20220318 IS - 1573-2509 (Electronic) IS - 0920-9964 (Print) IS - 0920-9964 (Linking) VI - 152 IP - 2-3 DP - 2014 Feb TI - Prodromal psychosis detection in a counseling center population in China: an epidemiological and clinical study. PG - 391-9 LID - S0920-9964(13)00653-1 [pii] LID - 10.1016/j.schres.2013.11.039 [doi] AB - BACKGROUND: To investigate through a two-stage clinic-based screening, the frequency and clinical features of risk for psychosis syndromes in a Chinese help-seeking sample. METHOD: 2101 consecutive new patients ages 15-45 were recruited at their first visit to the Shanghai Mental Health Center (SMHC) and screened with the Prodromal Questionnaire-Brief version (PQ-B) and questions about genetic risk. The Structured Interview for Prodromal Syndromes (SIPS) was administered to a sub-sample to estimate rates of psychosis and clinical high risk (CHR) for psychosis syndromes. RESULTS: The frequency estimate of CHR syndromes in the total sample was 4.2%. Among 89 CHR patients, more than two-thirds met the criteria for Attenuated Positive Symptom Syndrome (APSS); and nearly a quarter met the criteria for Genetic Risk and Deterioration Syndrome (GRDS). The frequency of CHR syndromes peaked between the ages of 16 and 21years old and declined with subsequent age. The mean total and distress scores on the PQ-B in subjects with APSS and psychosis were significantly higher than in individuals with GDRS and patients without psychosis or CHR. High frequencies and strong correlations were found among some positive and non-specific symptoms in SIPS interviews. Among the 53 CHR participants who were followed-up for two years, 14 (26.4%) converted to psychosis. Of the non-converters, 53.8% were diagnosed with Axis I disorders. CONCLUSIONS: This two stage screening method can enhance detection of Chinese CHR patients in clinical settings. The validity of the procedures for detecting CHR is supported by rates of transition to psychosis and of non-converter Axis I disorders that are comparable to those reported in meta-analyses. CI - Copyright (c) 2013 Elsevier B.V. All rights reserved. FAU - Zhang, Tianhong AU - Zhang T AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. FAU - Li, Huijun AU - Li H AD - Florida A&M University, Department of Psychology, Tallahassee, FL 32307, USA; Harvard Medical School, Department of Psychiatry, Beth Israel Deaconess Medical Center, 75 Fenwood Rd, Boston, MA 02115, USA. FAU - Woodberry, Kristen A AU - Woodberry KA AD - Harvard Medical School, Department of Psychiatry, Beth Israel Deaconess Medical Center, 75 Fenwood Rd, Boston, MA 02115, USA. FAU - Seidman, Larry J AU - Seidman LJ AD - Harvard Medical School, Department of Psychiatry, Beth Israel Deaconess Medical Center, 75 Fenwood Rd, Boston, MA 02115, USA. FAU - Zheng, Lina AU - Zheng L AD - Liaocheng People's Hospital, Shandong, PR China. FAU - Li, Hui AU - Li H AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. FAU - Zhao, Shanshan AU - Zhao S AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. FAU - Tang, Yingying AU - Tang Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. FAU - Guo, Qian AU - Guo Q AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. FAU - Lu, Xi AU - Lu X AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. FAU - Zhuo, Kaiming AU - Zhuo K AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. FAU - Qian, Zhenying AU - Qian Z AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. FAU - Chow, Annabelle AU - Chow A AD - Changi General Hospital, Department of Psychological Medicine, Singapore. FAU - Li, Chunbo AU - Li C AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. FAU - Jiang, Kaida AU - Jiang K AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. FAU - Xiao, Zeping AU - Xiao Z AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. Electronic address: xiao_zeping@126.com. FAU - Wang, Jijun AU - Wang J AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, PR China. Electronic address: jijunwang27@gmail.com. LA - eng GR - D43 TW005809/TW/FIC NIH HHS/United States GR - R21 MH093294/MH/NIMH NIH HHS/United States GR - 1R21 MH093294-01A1/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20131230 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adolescent MH - Adult MH - Age Factors MH - China/epidemiology MH - *Counseling MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Prodromal Symptoms MH - Psychiatric Status Rating Scales MH - Psychotherapy MH - Psychotic Disorders/*diagnosis/*epidemiology/therapy MH - Statistics, Nonparametric MH - Surveys and Questionnaires MH - Young Adult PMC - PMC4441955 MID - NIHMS688512 OTO - NOTNLM OT - Clinical high risk OT - Early detection OT - Epidemiology OT - Help-seeking OT - Ultra-high risk EDAT- 2014/01/07 06:00 MHDA- 2014/09/24 06:00 PMCR- 2015/05/24 CRDT- 2014/01/07 06:00 PHST- 2013/08/01 00:00 [received] PHST- 2013/11/17 00:00 [revised] PHST- 2013/11/29 00:00 [accepted] PHST- 2014/01/07 06:00 [entrez] PHST- 2014/01/07 06:00 [pubmed] PHST- 2014/09/24 06:00 [medline] PHST- 2015/05/24 00:00 [pmc-release] AID - S0920-9964(13)00653-1 [pii] AID - 10.1016/j.schres.2013.11.039 [doi] PST - ppublish SO - Schizophr Res. 2014 Feb;152(2-3):391-9. doi: 10.1016/j.schres.2013.11.039. Epub 2013 Dec 30.