PMID- 24388726
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 215
IP  - 2
DP  - 2014 Feb 28
TI  - Alexithymia as a risk factor for type 2 diabetes mellitus in the metabolic 
      syndrome: a cross-sectional study.
PG  - 438-43
LID - S0165-1781(13)00767-1 [pii]
LID - 10.1016/j.psychres.2013.12.004 [doi]
AB  - Alexithymia is a clinical trait consisting of diminished introspective and 
      interoceptive capacities that has been shown to implicate elevated autonomic 
      outflow and to bias for hypertension. To estimate relative risk associated with 
      alexithymia in the metabolic syndrome (MetS), we conducted a cross-sectional 
      analysis of patients with manifest type 2 diabetes mellitus (T2DM) or familial 
      diabetes risk (N=101; 67 females; age 45.6+/-13.96) in a nationwide sampled 
      treatment cohort for MetS in the Ukrainian governmental health care system. 
      Laboratory data of single components of the MetS according to International 
      Diabetes Federation Consensus were dependent measures in multivariable regression 
      models with self-reported alexithymia severity (TAS-20) and socio-demographic 
      data. TAS-20 as the sole surviving psychometric predictor for T2DM in the 
      simplest regression equation provided the best model fit: OR 1.073, Z=19.04, 
      (95%CIs 1.065-1.081). For microalbuminuria, the best fitting model was OR 1.030, 
      Z=3.49 (95%CIs 1.013-1.048). TAS-20 predicted also triglyceride level at 
      Wald-chi(2)=1299.27, Z=36.05 (95%CIs 0.052-0.058) and blood pressure maximum at 
      Wald-chi(2)=2309.05, Z=48.05 (95%CIs 2.402-2.606). Our results show that 
      alexithymia severity contributes to MetS by covarying with several of its single 
      components, and that it may be a substantial concurrent indicator of T2DM and 
      cardiovascular risks in MetS.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Lemche, Alexandra V
AU  - Lemche AV
AD  - Department of Psychosomatic Medicine, Charite University Medicine Berlin, 
      Germany.
FAU - Chaban, Oleg S
AU  - Chaban OS
AD  - Section of Neuroses and Somatoform Disorders, Bogolomets National Medical 
      University, Kiev, Ukraine.
FAU - Lemche, Erwin
AU  - Lemche E
AD  - Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King's College 
      London, UK. Electronic address: erwin.lemche@kcl.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131214
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - Affective Symptoms/*complications/psychology
MH  - Blood Pressure
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*etiology/psychology
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Hypertension/*complications/psychology
MH  - Male
MH  - Metabolic Syndrome/*complications/psychology
MH  - Middle Aged
MH  - Risk Factors
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Cross-sectional studies
OT  - Metabolic syndrome
OT  - National cohort
OT  - Relative risk
OT  - Toronto Alexithymia Scale
OT  - Type 2 diabetes mellitus
EDAT- 2014/01/07 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/07 06:00
PHST- 2012/06/16 00:00 [received]
PHST- 2013/08/13 00:00 [revised]
PHST- 2013/12/04 00:00 [accepted]
PHST- 2014/01/07 06:00 [entrez]
PHST- 2014/01/07 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0165-1781(13)00767-1 [pii]
AID - 10.1016/j.psychres.2013.12.004 [doi]
PST - ppublish
SO  - Psychiatry Res. 2014 Feb 28;215(2):438-43. doi: 10.1016/j.psychres.2013.12.004. 
      Epub 2013 Dec 14.