PMID- 24390400
OWN - NLM
STAT- MEDLINE
DCOM- 20140822
LR  - 20220309
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 252
IP  - 3
DP  - 2014 Mar
TI  - The effect of intracameral anesthesia on macular thickness and ganglion 
      cell-inner plexiform layer thickness after uneventful phacoemulsification 
      surgery: prospective and randomized controlled trial.
PG  - 433-9
LID - 10.1007/s00417-013-2557-3 [doi]
AB  - BACKGROUND: To evaluate the effect of intracameral lidocaine anesthesia on 
      macular thickness and macular ganglion cell-inner plexiform layer (GC-IPL) 
      thickness following uneventful phacoemusification in healthy subjects. METHODS: 
      This is a prospective, randomized and double- masked study. One hundred eyes of 
      74 consecutive patients were randomized to receive intracameral preservative-free 
      lidocaine 1 % (intracameral lidocaine group) or intracameral injection of 
      balanced salt solution (sham injection group) at the time of the 
      phacoemulsification surgery. Preoperative and postoperative macular thickness 
      analyses with spectral domain optical coherence tomography (SD-ODT) were 
      performed and the results between the two groups were compared. RESULTS: 
      Postoperatively, both the central foveal thickness (CFT) and the thickness of 
      perifoveal macula were significantly improved in both groups (p < 0.001). There 
      was no statistically significant difference between CFT and the inner and outer 
      macular zone thicknesses of the two groups at any follow-up time. In both groups, 
      GC-IPL thickness was significantly increased at the first week and first month 
      visits (p < 0.001). There was no statistically significant difference between 
      GC-IPL thickness measurements of the two groups at any follow-up time. 
      CONCLUSION: The current study demonstrated that supplementary intracameral 
      lidocaine 1 % did not cause more macular thickening than the intracameral sham 
      injection during a follow-up period of 3 months. The present study also showed a 
      tendency for a transient increase in high definition SD-OCT-based GC-IPL 
      thickness measurements within a few months following cataract surgery under both 
      intracameral lidocaine anesthesia and intracameral sham injection.
FAU - Sari, Esin Sogutlu
AU  - Sari ES
AD  - Faculty of Medicine, Department of Ophthalmology, Balikesir University, 
      Balikesir, Turkey, dresinsogutlu@gmail.com.
FAU - Ermis, Sitki Samet
AU  - Ermis SS
FAU - Yazici, Alper
AU  - Yazici A
FAU - Koytak, Arif
AU  - Koytak A
FAU - Sahin, Gozde
AU  - Sahin G
FAU - Kilic, Adil
AU  - Kilic A
LA  - eng
SI  - ISRCTN/ISRCTN94155463
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20140105
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
RN  - 0 (Anesthetics, Local)
RN  - 98PI200987 (Lidocaine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anesthesia, Local/*methods
MH  - Anesthetics, Local/*administration & dosage
MH  - Anterior Chamber/drug effects
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Injections, Intraocular
MH  - Lens Implantation, Intraocular
MH  - Lidocaine/*administration & dosage
MH  - Macula Lutea/*anatomy & histology
MH  - Male
MH  - Middle Aged
MH  - *Phacoemulsification
MH  - Prospective Studies
MH  - Retinal Bipolar Cells/*cytology
MH  - Retinal Ganglion Cells/*cytology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2014/01/07 06:00
MHDA- 2014/08/26 06:00
CRDT- 2014/01/07 06:00
PHST- 2013/09/05 00:00 [received]
PHST- 2013/12/17 00:00 [accepted]
PHST- 2013/12/05 00:00 [revised]
PHST- 2014/01/07 06:00 [entrez]
PHST- 2014/01/07 06:00 [pubmed]
PHST- 2014/08/26 06:00 [medline]
AID - 10.1007/s00417-013-2557-3 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2014 Mar;252(3):433-9. doi: 
      10.1007/s00417-013-2557-3. Epub 2014 Jan 5.