PMID- 24390521
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 53
IP  - 1
DP  - 2014
TI  - Prediction of congestive heart failure in patients with non valvular atrial 
      fibrillation.
PG  - 7-12
AB  - OBJECTIVE: Patients with atrial fibrillation (AF) have an increased risk of 
      congestive heart failure (CHF) as well as ischemic stroke. The aim of this study 
      was to investigate the clinical predictors of CHF in patients with non-valvular 
      AF (NVAF). METHODS: Three hundred and forty-seven patients (derivation cohort) 
      with NVAF were retrospectively evaluated between 2004 and 2005. The associations 
      between potential risk factors and CHF were tested using a Cox proportional 
      hazards analysis, and a risk score for predicting CHF was created. The model was 
      then validated in 161 patients (validation cohort) enrolled between 2008 and 
      2010. During the follow-up period, 41 patients in the derivation cohort developed 
      CHF requiring hospitalization due to New York Heart Association (NYHA) class III 
      or IV disease. Four independent risk factors were identified, each of which was 
      assigned a number of points as follows: Age >/=72 years (1 point), heart rate >/=80 
      bpm (1 point), hypertension (1 point), and a previous history of congestive heart 
      failure (2 points). The patients were grouped into one of three risk categories 
      according to the calculated risk score (ARC2H score): low risk (0 points), 
      intermediate risk (1-3 points) and high risk (4-5 points). RESULT: In the 
      derivation cohort, the annual rates of CHF in these risk categories were 0%, 2.5% 
      and 18% per year respectively. In the validation cohort, the corresponding rates 
      were 0.8%, 8% and 35% per year respectively. CONCLUSION: A simple clinical risk 
      score, the ARC2H score, was developed to predict CHF in patients with NVAF and 
      validated in an independent cohort.
FAU - Imai, Koichiro
AU  - Imai K
AD  - Department of Cardiology, Kawasaki Medical School, Japan.
FAU - Okura, Hiroyuki
AU  - Okura H
FAU - Tamada, Tomoko
AU  - Tamada T
FAU - Fukuhara, Kenzo
AU  - Fukuhara K
FAU - Koyama, Terumasa
AU  - Koyama T
FAU - Kume, Teruyoshi
AU  - Kume T
FAU - Hayashida, Akihiro
AU  - Hayashida A
FAU - Kawamoto, Takahiro
AU  - Kawamoto T
FAU - Neishi, Yoji
AU  - Neishi Y
FAU - Yoshida, Kiyoshi
AU  - Yoshida K
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Fibrillation/*complications/*diagnosis
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*diagnosis/*etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2014/01/07 06:00
MHDA- 2014/09/03 06:00
CRDT- 2014/01/07 06:00
PHST- 2014/01/07 06:00 [entrez]
PHST- 2014/01/07 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
AID - DN/JST.JSTAGE/internalmedicine/53.0962 [pii]
AID - 10.2169/internalmedicine.53.0962 [doi]
PST - ppublish
SO  - Intern Med. 2014;53(1):7-12. doi: 10.2169/internalmedicine.53.0962.