PMID- 24391022
OWN - NLM
STAT- MEDLINE
DCOM- 20150818
LR  - 20220316
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 41
IP  - 1
DP  - 2015 Jan
TI  - Validation of a golden angle radial sequence (GOLD) for abdominal T1 mapping 
      during free breathing: demonstrating clinical feasibility for quantifying gastric 
      secretion and emptying.
PG  - 157-64
LID - 10.1002/jmri.24530 [doi]
AB  - PURPOSE: To validate a magnetic resonance imaging sequence suitable for 
      quantitative assessment of acid suppression by a proton pump inhibitor (PPI) on 
      gastric secretion and emptying in clinical practice. METHODS: A golden angle 
      radial sequence (GOLD) was validated in a series of in vitro and in vivo 
      experiments and clinical feasibility was shown in two studies. The impact of free 
      breathing and image plane orientation on T1 values was evaluated in a controlled 
      in vivo experiment. The free-breathing GOLD sequence was compared against a 
      standard breath-hold gradient echo sequence for gastric half emptying time in 23 
      subjects during a gastric emptying study. Pilot data from five subjects assessed 
      the sensitivity of the GOLD sequence to detect changes in acid secretion volume 
      produced by PPI treatment. RESULTS: The coronal free-breathing GOLD sequence and 
      the axial breath-hold standard gradient echo sequence showed good agreement of 
      the gastric half emptying time (6 +/- 3 min, P = 0.053). The GOLD sequence 
      demonstrated sensitivity to reduction of gastric secretion volumes induced by PPI 
      treatment (55 +/- 5 mL, P < 0.001). CONCLUSION: The GOLD sequence allowed for free 
      breathing, multislice, combined imaging and T1 mapping of the stomach content. 
      GOLD presents a promising multipurpose, noninvasive imaging tool for monitoring 
      gastric function in clinical studies.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Curcic, Jelena
AU  - Curcic J
AD  - Institute for Biomedical Engineering, University and ETH Zurich, Zurich, 
      Switzerland; Division of Gastroenterology and Hepatology, University Hospital 
      Zurich, Zurich, Switzerland.
FAU - Sauter, Matthias
AU  - Sauter M
FAU - Schwizer, Werner
AU  - Schwizer W
FAU - Fried, Michael
AU  - Fried M
FAU - Boesiger, Peter
AU  - Boesiger P
FAU - Steingoetter, Andreas
AU  - Steingoetter A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20140106
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Proton Pump Inhibitors)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
MH  - Abdomen
MH  - Adult
MH  - Contrast Media
MH  - Feasibility Studies
MH  - Female
MH  - Gastric Emptying/*physiology
MH  - Gastric Juice/*metabolism
MH  - Gastroesophageal Reflux/drug therapy/*physiopathology
MH  - Gastrointestinal Tract/drug effects/*physiopathology
MH  - Humans
MH  - Image Enhancement
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Meglumine
MH  - Middle Aged
MH  - Organometallic Compounds
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Respiration
MH  - Sensitivity and Specificity
MH  - Single-Blind Method
OTO - NOTNLM
OT  - T1 mapping
OT  - gastric secretion
OT  - gastroesophageal reflux disease
OT  - golden angle
OT  - proton pump inhibitors
EDAT- 2014/01/07 06:00
MHDA- 2015/08/19 06:00
CRDT- 2014/01/07 06:00
PHST- 2013/07/16 00:00 [received]
PHST- 2013/11/14 00:00 [accepted]
PHST- 2014/01/07 06:00 [entrez]
PHST- 2014/01/07 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
AID - 10.1002/jmri.24530 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2015 Jan;41(1):157-64. doi: 10.1002/jmri.24530. Epub 2014 
      Jan 6.