PMID- 24391311 OWN - NLM STAT- MEDLINE DCOM- 20141014 LR - 20211021 IS - 1526-6702 (Electronic) IS - 0730-2347 (Print) IS - 0730-2347 (Linking) VI - 40 IP - 5 DP - 2013 TI - Low serum triglyceride levels as predictors of cardiac death in heart failure patients. PG - 521-8 AB - Understanding the influence of sex differences on predictors of cardiac mortality rates in chronic heart failure might enable us to lengthen lifetimes and to improve lives. This study describes the influence of sex on cardiovascular mortality rates among chronic heart failure patients. From January 2003 through December 2009, we evaluated 637 consecutive patients (409 men and 228 women) with chronic heart failure, who ranged in age from 18 through 94 years (mean age, 64 +/- 13 yr) and ranged in New York Heart Association (NYHA) functional class from II through IV. The mean follow-up period was 38 +/- 15 months, the mean age was 64 +/- 13 years, and the mean left ventricular ejection fraction was 0.27 +/-0.11. By the end of the study, both sexes had similar cardiovascular mortality rates (36% men vs 37% women, P=0.559). In Cox regression analysis, NYHA functional class, triglyceride level, and history of coronary artery disease were independent predictors of cardiovascular death for women with chronic heart failure. For men with chronic heart failure, the patient's age, ejection fraction, and sodium level were independent predictors of cardiovascular death. In a modern tertiary referral heart failure clinic, decreased triglyceride levels were, upon univariate analysis, predictors of poor outcomes for both men and women. However, upon Cox regression analysis, reduced triglyceride levels were independent predictors of cardiac death only in women. FAU - Kozdag, Guliz AU - Kozdag G AD - Departments of Cardiology (Drs. Akay, Celikyurt, Emre, Ertas, Karauzum, Kozdag, Sahin, Ural, and Yilmaz) and Nuclear Medicine (Dr. Gorur), Faculty of Medicine, Kocaeli University, 41300 Kocaeli, Turkey; and Charles E. Schmidt College of Medicine (Dr. Sarsekeyeva), Florida Atlantic University, Boca Raton, Florida 33431. FAU - Ertas, Gokhan AU - Ertas G AD - Departments of Cardiology (Drs. Akay, Celikyurt, Emre, Ertas, Karauzum, Kozdag, Sahin, Ural, and Yilmaz) and Nuclear Medicine (Dr. Gorur), Faculty of Medicine, Kocaeli University, 41300 Kocaeli, Turkey; and Charles E. Schmidt College of Medicine (Dr. Sarsekeyeva), Florida Atlantic University, Boca Raton, Florida 33431. FAU - Emre, Ender AU - Emre E AD - Departments of Cardiology (Drs. Akay, Celikyurt, Emre, Ertas, Karauzum, Kozdag, Sahin, Ural, and Yilmaz) and Nuclear Medicine (Dr. Gorur), Faculty of Medicine, Kocaeli University, 41300 Kocaeli, Turkey; and Charles E. Schmidt College of Medicine (Dr. Sarsekeyeva), Florida Atlantic University, Boca Raton, Florida 33431. FAU - Akay, Yasar AU - Akay Y AD - Departments of Cardiology (Drs. Akay, Celikyurt, Emre, Ertas, Karauzum, Kozdag, Sahin, Ural, and Yilmaz) and Nuclear Medicine (Dr. Gorur), Faculty of Medicine, Kocaeli University, 41300 Kocaeli, Turkey; and Charles E. Schmidt College of Medicine (Dr. Sarsekeyeva), Florida Atlantic University, Boca Raton, Florida 33431. FAU - Celikyurt, Umut AU - Celikyurt U AD - Departments of Cardiology (Drs. Akay, Celikyurt, Emre, Ertas, Karauzum, Kozdag, Sahin, Ural, and Yilmaz) and Nuclear Medicine (Dr. Gorur), Faculty of Medicine, Kocaeli University, 41300 Kocaeli, Turkey; and Charles E. Schmidt College of Medicine (Dr. Sarsekeyeva), Florida Atlantic University, Boca Raton, Florida 33431. FAU - Sahin, Tayfun AU - Sahin T AD - Departments of Cardiology (Drs. Akay, Celikyurt, Emre, Ertas, Karauzum, Kozdag, Sahin, Ural, and Yilmaz) and Nuclear Medicine (Dr. Gorur), Faculty of Medicine, Kocaeli University, 41300 Kocaeli, Turkey; and Charles E. Schmidt College of Medicine (Dr. Sarsekeyeva), Florida Atlantic University, Boca Raton, Florida 33431. FAU - Gorur, Gozde AU - Gorur G AD - Departments of Cardiology (Drs. Akay, Celikyurt, Emre, Ertas, Karauzum, Kozdag, Sahin, Ural, and Yilmaz) and Nuclear Medicine (Dr. Gorur), Faculty of Medicine, Kocaeli University, 41300 Kocaeli, Turkey; and Charles E. Schmidt College of Medicine (Dr. Sarsekeyeva), Florida Atlantic University, Boca Raton, Florida 33431. FAU - Karauzum, Kurtulus AU - Karauzum K AD - Departments of Cardiology (Drs. Akay, Celikyurt, Emre, Ertas, Karauzum, Kozdag, Sahin, Ural, and Yilmaz) and Nuclear Medicine (Dr. Gorur), Faculty of Medicine, Kocaeli University, 41300 Kocaeli, Turkey; and Charles E. Schmidt College of Medicine (Dr. Sarsekeyeva), Florida Atlantic University, Boca Raton, Florida 33431. FAU - Yilmaz, Irem AU - Yilmaz I AD - Departments of Cardiology (Drs. Akay, Celikyurt, Emre, Ertas, Karauzum, Kozdag, Sahin, Ural, and Yilmaz) and Nuclear Medicine (Dr. Gorur), Faculty of Medicine, Kocaeli University, 41300 Kocaeli, Turkey; and Charles E. Schmidt College of Medicine (Dr. Sarsekeyeva), Florida Atlantic University, Boca Raton, Florida 33431. FAU - Ural, Dilek AU - Ural D AD - Departments of Cardiology (Drs. Akay, Celikyurt, Emre, Ertas, Karauzum, Kozdag, Sahin, Ural, and Yilmaz) and Nuclear Medicine (Dr. Gorur), Faculty of Medicine, Kocaeli University, 41300 Kocaeli, Turkey; and Charles E. Schmidt College of Medicine (Dr. Sarsekeyeva), Florida Atlantic University, Boca Raton, Florida 33431. FAU - Sarsekeyeva, Mira AU - Sarsekeyeva M AD - Departments of Cardiology (Drs. Akay, Celikyurt, Emre, Ertas, Karauzum, Kozdag, Sahin, Ural, and Yilmaz) and Nuclear Medicine (Dr. Gorur), Faculty of Medicine, Kocaeli University, 41300 Kocaeli, Turkey; and Charles E. Schmidt College of Medicine (Dr. Sarsekeyeva), Florida Atlantic University, Boca Raton, Florida 33431. LA - eng PT - Journal Article PL - United States TA - Tex Heart Inst J JT - Texas Heart Institute journal JID - 8214622 RN - 0 (Biomarkers) RN - 0 (Triglycerides) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Biomarkers/blood MH - Death, Sudden, Cardiac/epidemiology/*etiology MH - Female MH - Follow-Up Studies MH - Heart Failure/blood/*complications/mortality MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Prognosis MH - Retrospective Studies MH - Risk Assessment/*methods MH - Risk Factors MH - Survival Rate/trends MH - Triglycerides/*blood MH - United States/epidemiology MH - Young Adult PMC - PMC3853839 OTO - NOTNLM OT - Cachexia/blood OT - chronic disease OT - female OT - follow-up studies OT - heart failure/mortality OT - male OT - predictive value of tests OT - prognosis OT - risk assessment OT - sex factors OT - survival analysis OT - triglycerides/blood OT - univariate analysis EDAT- 2014/01/07 06:00 MHDA- 2014/10/15 06:00 PMCR- 2013/01/01 CRDT- 2014/01/07 06:00 PHST- 2014/01/07 06:00 [entrez] PHST- 2014/01/07 06:00 [pubmed] PHST- 2014/10/15 06:00 [medline] PHST- 2013/01/01 00:00 [pmc-release] AID - 0010801-201312000-00005 [pii] PST - ppublish SO - Tex Heart Inst J. 2013;40(5):521-8.