PMID- 24391458
OWN - NLM
STAT- MEDLINE
DCOM- 20140715
LR  - 20211021
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 2013
DP  - 2013
TI  - Pharmacokinetic delivery and metabolizing rate of nicardipine incorporated in 
      hydrophilic and hydrophobic cyclodextrins using two-compartment mathematical 
      model.
PG  - 131358
LID - 10.1155/2013/131358 [doi]
LID - 131358
AB  - The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as 
      hydrophilic hydroxypropyl-beta-cyclodextrin (NC/HPbetaCD) and hydrophobic 
      triacetyl-beta-cyclodextrin (NC/TAbetaCD), through the body for controlled drug 
      delivery and sustained release have been examined. The two-compartment 
      pharmacokinetic model described the mechanisms of how the human body handles with 
      ingestion of NC-cyclodextrin complexes in gastrointestinal tract (GI), 
      distribution in plasma, and their metabolism in the liver. The model showed that 
      drug bioavailability was significantly improved after oral administration of 
      cyclodextrin complexes. The mathematical significance of this study to predict 
      nicardipine delivery using pharmacokinetic two-compartment mathematical model 
      with linear ordinary differential equations (ODE) approach represents a valuable 
      tool to emphasize its effectiveness and metabolizing rate and diminish the side 
      effects.
FAU - Shityakov, Sergey
AU  - Shityakov S
AD  - Department of Anaesthesia and Critical Care, University of Wurzburg, 97080 
      Wurzburg, Germany.
FAU - Forster, Carola
AU  - Forster C
AD  - Department of Anaesthesia and Critical Care, University of Wurzburg, 97080 
      Wurzburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131203
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Cyclodextrins)
RN  - 0 (beta-Cyclodextrins)
RN  - CZ5312222S (Nicardipine)
RN  - JV039JZZ3A (betadex)
SB  - IM
MH  - Administration, Oral
MH  - Algorithms
MH  - Animals
MH  - Antihypertensive Agents/administration & dosage/pharmacokinetics
MH  - Chromatography, Liquid
MH  - Computer Simulation
MH  - Cyclodextrins/blood/*chemistry
MH  - Dose-Response Relationship, Drug
MH  - Drug Delivery Systems
MH  - Gastrointestinal Tract/drug effects
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Liver/drug effects/metabolism
MH  - Models, Theoretical
MH  - Nicardipine/administration & dosage/*pharmacokinetics
MH  - Rabbits
MH  - Software
MH  - beta-Cyclodextrins/chemistry
PMC - PMC3866780
EDAT- 2014/01/07 06:00
MHDA- 2014/07/16 06:00
PMCR- 2013/12/03
CRDT- 2014/01/07 06:00
PHST- 2013/08/03 00:00 [received]
PHST- 2013/09/06 00:00 [accepted]
PHST- 2014/01/07 06:00 [entrez]
PHST- 2014/01/07 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
PHST- 2013/12/03 00:00 [pmc-release]
AID - 10.1155/2013/131358 [doi]
PST - epublish
SO  - ScientificWorldJournal. 2013 Dec 3;2013:131358. doi: 10.1155/2013/131358. 
      eCollection 2013.