PMID- 24391674
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2013
DP  - 2013
TI  - Extracts of Tripterygium wilfordii Hook F in the Treatment of Rheumatoid 
      Arthritis: A Systemic Review and Meta-Analysis of Randomised Controlled Trials.
PG  - 410793
LID - 10.1155/2013/410793 [doi]
LID - 410793
AB  - Clinical trials have reported the effects of Tripterygium wilfordii Hook F (TwHF) 
      extracts (TEs) in the treatment of rheumatoid arthritis (RA); however, the 
      results have been inconsistent. This meta-analysis is aimed to assess the safety 
      of TEs and their effects on the treatment of RA. Randomised controlled trials 
      (RCTs) comparing the effects of TEs and placebo (PBO) or disease-modifying 
      antirheumatic drugs (DMARDs) in patients with RA were included. Weighted mean 
      differences (MDs) were calculated for net changes by employing fixed-effect or 
      random-effects models. After filtering, ten RCTs (involving 733 participants) 
      were included in this study. The methodological quality of these studies was 
      generally low. Compared with DMARDs, TEs alone produced a mild increase in grip 
      strength (GS) (P = 0.02; standard mean difference (SMD) = 0.81; 95% confidence 
      interval (CI): 0.14 to 1.48). The most common adverse effects (AEs) of TEs were 
      gastrointestinal discomfort, menstruation disorders, and amenorrhea. In 
      conclusion, TEs, as a sort of "herbal DMARD," could be as effective as synthetic 
      DMARDs in the treatment of RA. However, the efficacy of TEs in treating RA should 
      be further estimated with better designed, fully powered, confirmatory RCTs that 
      apply the American College of Rheumatology (ACR) improvement criteria to evaluate 
      their outcomes.
FAU - Liu, Yafei
AU  - Liu Y
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Tongji 
      Hospital, Tongji Medical College, Huazhong University of Science and Technology, 
      1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
FAU - Tu, Shenghao
AU  - Tu S
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Tongji 
      Hospital, Tongji Medical College, Huazhong University of Science and Technology, 
      1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
FAU - Gao, Weina
AU  - Gao W
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Tongji 
      Hospital, Tongji Medical College, Huazhong University of Science and Technology, 
      1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Tongji 
      Hospital, Tongji Medical College, Huazhong University of Science and Technology, 
      1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
FAU - Liu, Peilin
AU  - Liu P
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Tongji 
      Hospital, Tongji Medical College, Huazhong University of Science and Technology, 
      1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
FAU - Hu, Yonghong
AU  - Hu Y
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Tongji 
      Hospital, Tongji Medical College, Huazhong University of Science and Technology, 
      1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
FAU - Dong, Hui
AU  - Dong H
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Tongji 
      Hospital, Tongji Medical College, Huazhong University of Science and Technology, 
      1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131204
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3866793
EDAT- 2014/01/07 06:00
MHDA- 2014/01/07 06:01
PMCR- 2013/12/04
CRDT- 2014/01/07 06:00
PHST- 2013/06/06 00:00 [received]
PHST- 2013/09/25 00:00 [accepted]
PHST- 2014/01/07 06:00 [entrez]
PHST- 2014/01/07 06:00 [pubmed]
PHST- 2014/01/07 06:01 [medline]
PHST- 2013/12/04 00:00 [pmc-release]
AID - 10.1155/2013/410793 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2013;2013:410793. doi: 10.1155/2013/410793. 
      Epub 2013 Dec 4.