PMID- 24391816
OWN - NLM
STAT- MEDLINE
DCOM- 20140918
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 12
DP  - 2013
TI  - Roux-en-Y gastric bypass increases intravenous ethanol self-administration in 
      dietary obese rats.
PG  - e83741
LID - 10.1371/journal.pone.0083741 [doi]
LID - e83741
AB  - Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment for severe 
      obesity. Clinical studies however have reported susceptibility to increased 
      alcohol use after RYGB, and preclinical studies have shown increased alcohol 
      intake in obese rats after RYGB. This could reflect a direct enhancement of 
      alcohol's rewarding effects in the brain or an indirect effect due to increased 
      alcohol absorption after RGYB. To rule out the contribution that changes in 
      alcohol absorption have on its rewarding effects, here we assessed the effects of 
      RYGB on intravenously (IV) administered ethanol (1%). For this purpose, high fat 
      (60% kcal from fat) diet-induced obese male Sprague Dawley rats were tested ~2 
      months after RYGB or sham surgery (SHAM) using both fixed and progressive ratio 
      schedules of reinforcement to evaluate if RGYB modified the reinforcing effects 
      of IV ethanol. Compared to SHAM, RYGB rats made significantly more active spout 
      responses to earn IV ethanol during the fixed ratio schedule, and achieved higher 
      breakpoints during the progressive ratio schedule. Although additional studies 
      are needed, our results provide preliminary evidence that RYGB increases the 
      rewarding effects of alcohol independent of its effects on alcohol absorption.
FAU - Polston, James E
AU  - Polston JE
AD  - Department of Neural and Behavioral Sciences, The Pennsylvania State University 
      College of Medicine, Hershey, Pennsylvania, United States of America.
FAU - Pritchett, Carolyn E
AU  - Pritchett CE
AD  - Department of Neural and Behavioral Sciences, The Pennsylvania State University 
      College of Medicine, Hershey, Pennsylvania, United States of America.
FAU - Tomasko, Jonathan M
AU  - Tomasko JM
AD  - Department of Surgery, The Pennsylvania State University College of Medicine, 
      Hershey, Pennsylvania, United States of America.
FAU - Rogers, Ann M
AU  - Rogers AM
AD  - Department of Surgery, The Pennsylvania State University College of Medicine, 
      Hershey, Pennsylvania, United States of America.
FAU - Leggio, Lorenzo
AU  - Leggio L
AD  - Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, 
      Laboratory of Clinical and Translational Studies, National Institute on Alcohol 
      Abuse and Alcoholism (NIAAA), NIH, Bethesda, Maryland, United States of America ; 
      Intramural Research Program, National Institute on Drug Abuse (NIDA), NIH, 
      Baltimore, Maryland, United States of America ; Department of Behavioral and 
      Social Sciences, Brown University, Providence, Rhode Island, United States of 
      America.
FAU - Thanos, Panayotis K
AU  - Thanos PK
AD  - Department of Psychology, Stony Brook University, Stony Brook, New York, United 
      States of America.
FAU - Volkow, Nora D
AU  - Volkow ND
AD  - Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, Maryland, 
      United States of America.
FAU - Hajnal, Andras
AU  - Hajnal A
AD  - Department of Neural and Behavioral Sciences, The Pennsylvania State University 
      College of Medicine, Hershey, Pennsylvania, United States of America ; Department 
      of Surgery, The Pennsylvania State University College of Medicine, Hershey, 
      Pennsylvania, United States of America.
LA  - eng
GR  - R01 DK080899/DK/NIDDK NIH HHS/United States
GR  - DK080899/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131231
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Administration, Intravenous
MH  - Alcohol Drinking/*adverse effects
MH  - Alcohol-Related Disorders/*etiology/physiopathology
MH  - Animals
MH  - Body Weight/physiology
MH  - Central Nervous System Depressants/*administration & dosage/pharmacology
MH  - Diet, High-Fat/adverse effects
MH  - Ethanol/*administration & dosage/pharmacology
MH  - Gastric Bypass/*adverse effects
MH  - Male
MH  - Obesity/complications/physiopathology/*surgery
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
PMC - PMC3877092
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/01/07 06:00
MHDA- 2014/09/19 06:00
PMCR- 2013/12/31
CRDT- 2014/01/07 06:00
PHST- 2013/08/22 00:00 [received]
PHST- 2013/11/05 00:00 [accepted]
PHST- 2014/01/07 06:00 [entrez]
PHST- 2014/01/07 06:00 [pubmed]
PHST- 2014/09/19 06:00 [medline]
PHST- 2013/12/31 00:00 [pmc-release]
AID - PONE-D-13-35056 [pii]
AID - 10.1371/journal.pone.0083741 [doi]
PST - epublish
SO  - PLoS One. 2013 Dec 31;8(12):e83741. doi: 10.1371/journal.pone.0083741. 
      eCollection 2013.