PMID- 24392843
OWN - NLM
STAT- MEDLINE
DCOM- 20141231
LR  - 20211021
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Print)
IS  - 0897-7151 (Linking)
VI  - 31
IP  - 10
DP  - 2014 May 15
TI  - Diffusion tensor imaging reveals white matter injury in a rat model of repetitive 
      blast-induced traumatic brain injury.
PG  - 938-50
LID - 10.1089/neu.2013.3144 [doi]
AB  - Blast-induced traumatic brain injury (bTBI) is one of the most common 
      combat-related injuries seen in U.S. military personnel, yet relatively little is 
      known about the underlying mechanisms of injury. In particular, the effects of 
      the primary blast pressure wave are poorly understood. Animal models have proven 
      invaluable for the study of primary bTBI, because it rarely occurs in isolation 
      in human subjects. Even less is known about the effects of repeated primary blast 
      wave exposure, but existing data suggest cumulative increases in brain damage 
      with a second blast. MRI and, in particular, diffusion tensor imaging (DTI), have 
      become important tools for assessing bTBI in both clinical and preclinical 
      settings. Computational statistical methods such as voxelwise analysis have shown 
      promise in localizing and quantifying bTBI throughout the brain. In this study, 
      we use voxelwise analysis of DTI to quantify white matter injury in a rat model 
      of repetitive primary blast exposure. Our results show a significant increase in 
      microstructural damage with a second blast exposure, suggesting that primary bTBI 
      may sensitize the brain to subsequent injury.
FAU - Calabrese, Evan
AU  - Calabrese E
AD  - 1 Center for In Vivo Microscopy, Department of Radiology, Duke University Medical 
      Center , Durham, North Carolina.
FAU - Du, Fu
AU  - Du F
FAU - Garman, Robert H
AU  - Garman RH
FAU - Johnson, G Allan
AU  - Johnson GA
FAU - Riccio, Cory
AU  - Riccio C
FAU - Tong, Lawrence C
AU  - Tong LC
FAU - Long, Joseph B
AU  - Long JB
LA  - eng
GR  - P41 EB015897/EB/NIBIB NIH HHS/United States
GR  - T32 GM007171/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140327
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
SB  - IM
MH  - Animals
MH  - Blast Injuries/*pathology
MH  - Brain Injuries/*pathology
MH  - Diffusion Tensor Imaging
MH  - Disease Models, Animal
MH  - Image Interpretation, Computer-Assisted
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - White Matter/*pathology
PMC - PMC4012630
EDAT- 2014/01/08 06:00
MHDA- 2015/01/01 06:00
PMCR- 2015/05/15
CRDT- 2014/01/08 06:00
PHST- 2014/01/08 06:00 [entrez]
PHST- 2014/01/08 06:00 [pubmed]
PHST- 2015/01/01 06:00 [medline]
PHST- 2015/05/15 00:00 [pmc-release]
AID - 10.1089/neu.2013.3144 [pii]
AID - 10.1089/neu.2013.3144 [doi]
PST - ppublish
SO  - J Neurotrauma. 2014 May 15;31(10):938-50. doi: 10.1089/neu.2013.3144. Epub 2014 
      Mar 27.