PMID- 24393242
OWN - NLM
STAT- MEDLINE
DCOM- 20150521
LR  - 20211021
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 14
DP  - 2014 Jan 7
TI  - Cynomorium songaricum extract enhances novel object recognition, cell 
      proliferation and neuroblast differentiation in the mice via improving 
      hippocampal environment.
PG  - 5
LID - 10.1186/1472-6882-14-5 [doi]
AB  - BACKGROUND: Cynomorium songaricum Rupr. (CS) has been used as a medicine to treat 
      many diseases as well as to alleviate age-related issues, such as memory 
      impairment, dementia, and stress. In this study, we assessed the effects of 
      Cynomorium songaricum extract (CSE) on the novel object recognition, cell 
      proliferation and neuroblast differentiation in the dentate gyrus of mice by 
      using 5-bromodeoxyuridine (BrdU) and polysialylated neural cell adhesion molecule 
      (PSA-NCAM). We also measured serum corticosterone levels to assess its 
      correlation with neurogenesis and stress. METHODS: Male C57BL/6 J mice were 
      divided into 3 groups: vehicle-treated, 40 mg/kg CSE-treated, and 100 mg/kg 
      CSE-treated. The vehicle and CSE were given to mice once a day for 3 weeks. BrdU 
      was injected twice a day for 3 days to label newly generated cells. RESULTS: 
      Administration of CSE significantly increased the preferential exploration of new 
      objects in these mice. In addition, administration of CSE decreased serum levels 
      of corticosterone. BrdU-positive cells as well as brain-derived neurotrophic 
      factor (BDNF) mRNA expression in the dentate gyrus were higher in the CSE-treated 
      groups than in the vehicle-treated group. PSA-NCAM-positive neuroblasts and their 
      well-developed tertiary dendrites were also significantly increased by the 
      treatment of CSE. These effects were prominent at the higher dosage than at the 
      lower dosage. CONCLUSION: These results suggest that administration of CSE 
      increases cell proliferation and neuroblast differentiation in the dentate gyrus 
      of mice by reducing serum corticosterone levels and increasing BDNF levels in 
      this area.
FAU - Yoo, Dae Young
AU  - Yoo DY
FAU - Choi, Jung Hoon
AU  - Choi JH
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine, and 
      Research Institute for Veterinary Science, Seoul National University, Seoul 
      151-742, South Korea. jhchoi@kangwon.ac.kr.
FAU - Kim, Woosuk
AU  - Kim W
FAU - Jung, Hyo Young
AU  - Jung HY
FAU - Nam, Sung Min
AU  - Nam SM
FAU - Kim, Jong Whi
AU  - Kim JW
FAU - Yoon, Yeo Sung
AU  - Yoon YS
FAU - Yoo, Ki-Yeon
AU  - Yoo KY
FAU - Won, Moo-Ho
AU  - Won MH
FAU - Hwang, In Koo
AU  - Hwang IK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140107
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Cell Proliferation/drug effects
MH  - Corticosterone/blood
MH  - Cynomorium/*chemistry
MH  - Dendrites/drug effects
MH  - Dentate Gyrus/cytology/*drug effects/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neural Stem Cells/cytology/drug effects
MH  - Neurogenesis/*drug effects
MH  - Plant Extracts/*pharmacology
MH  - RNA, Messenger/analysis/genetics
MH  - Recognition, Psychology/*drug effects
MH  - Stress, Psychological
PMC - PMC3893434
EDAT- 2014/01/08 06:00
MHDA- 2015/05/23 06:00
PMCR- 2014/01/07
CRDT- 2014/01/08 06:00
PHST- 2013/09/09 00:00 [received]
PHST- 2013/12/31 00:00 [accepted]
PHST- 2014/01/08 06:00 [entrez]
PHST- 2014/01/08 06:00 [pubmed]
PHST- 2015/05/23 06:00 [medline]
PHST- 2014/01/07 00:00 [pmc-release]
AID - 1472-6882-14-5 [pii]
AID - 10.1186/1472-6882-14-5 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2014 Jan 7;14:5. doi: 10.1186/1472-6882-14-5.