PMID- 24393475
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20151119
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 6
IP  - 5
DP  - 2014 Sep
TI  - Progression from impaired fasting glucose to type 2 diabetes mellitus among 
      Chinese subjects with and without hypertension in a primary care setting.
PG  - 438-46
LID - 10.1111/1753-0407.12120 [doi]
AB  - BACKGROUND: The progression from impaired fasting glucose (IFG) to type 2 
      diabetes mellitus (T2DM) in Chinese subjects, with and without hypertension, in a 
      primary care setting was unknown. METHODS: The present retrospective multicenter 
      5-year (2002-2007) cohort study was performed on IFG subjects attending 23 
      general outpatient clinics who were identified by their elevated fasting blood 
      glucose laboratory results. Development of T2DM was determined by physician 
      diagnosis of T2DM or starting of oral antidiabetic drugs within 5 years. The 
      relationship between the time of T2DM diagnosis and subject characteristics was 
      assessed by adjusted hazard ratios (aHR) from Cox hazards model. RESULTS: Of the 
      9161 IFG subjects, 4080 (45%) were men and 5081 (55%) were women. There were 1998 
      subjects who developed T2DM. The 5-year cumulative incidence was 0.218, whereas 
      the overall annual incidence rate was 5.981/100 person-years. Subjects were more 
      likely to develop T2DM if they were hypertensive (aHR = 1.44; 95% confidence 
      interval [CI] 1.28-1.62; P < 0.001), aged <60 years (aHR = 1.36, 95% CI 
      1.24-1.49; P < 0.001), female (aHR = 1.18, 95% CI 1.08-1.29; P < 0.001), and had 
      higher fasting glucose levels (6.39 +/- 0.49 vs 6.24 +/- 0.43 mmol/L in the group 
      that developed T2DM vs the group without T2DM, respectively; aHR = 2.01, 95% CI 
      1.83-2.20; P < 0.001). CONCLUSION: Overall, more than one-fifth of IFG subjects 
      in the primary care setting developed T2DM within 5 years. Health care 
      professionals can target interventions to patients with risk factors for disease 
      progression.
CI  - (c) 2014 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley 
      Publishing Asia Pty Ltd.
FAU - Fu, Sau Nga
AU  - Fu SN
AD  - Department of Family Medicine and Primary Health Care, Kowloon West Cluster, 
      Hospital Authority, Kowloon.
FAU - Luk, Wan
AU  - Luk W
FAU - Wong, Carlos King Ho
AU  - Wong CK
FAU - Cheung, Kwok Leung
AU  - Cheung KL
LA  - eng
SI  - ClinicalTrials.gov/NCT01807351
PT  - Journal Article
PT  - Multicenter Study
DEP - 20140218
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/drug therapy/*epidemiology
MH  - Disease Progression
MH  - Fasting/*blood
MH  - Female
MH  - Glucose Metabolism Disorders/blood/diagnosis/*epidemiology
MH  - Hong Kong/epidemiology
MH  - Humans
MH  - Hypertension/diagnosis
MH  - Hypoglycemic Agents/therapeutic use
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - *Primary Health Care
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sex Factors
MH  - Time Factors
OTO - NOTNLM
OT  - disease progression
OT  - hyperglycemia
OT  - hypertension
OT  - primary health care
OT  - type 2 diabetes mellitus
OT  - 关键词：疾病进展，高血糖，高血压，初级卫生保健，2型糖尿病
EDAT- 2014/01/08 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/01/08 06:00
PHST- 2013/09/17 00:00 [received]
PHST- 2013/12/10 00:00 [revised]
PHST- 2013/12/17 00:00 [accepted]
PHST- 2014/01/08 06:00 [entrez]
PHST- 2014/01/08 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - 10.1111/1753-0407.12120 [doi]
PST - ppublish
SO  - J Diabetes. 2014 Sep;6(5):438-46. doi: 10.1111/1753-0407.12120. Epub 2014 Feb 18.