PMID- 24393856
OWN - NLM
STAT- MEDLINE
DCOM- 20140310
LR  - 20201219
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 40
IP  - 12
DP  - 2013 Nov
TI  - [Treatment outcome of peptide vaccination for advanced colorectal cancer].
PG  - 1584-6
AB  - Complementary DNA( cDNA) microarray technology coupled with laser microdissection 
      has been used to identify human leukocyte antigen (HLA)-A24-restricted epitope 
      peptides as potential targets for cancer vaccination in colorectal cancer 
      patients. These antigenic peptides were derived from 2 different cancer-testis 
      antigens, ring finger protein 43 (RNF43) and translocase of outer mitochondrial 
      membrane 34( TOMM34). We conducted a clinical trial of colorectal cancer-specific 
      peptide( RNF43, TOMM34) vaccines with uracil/tegafur( UFT)+Leucovorin( LV) for 
      the treatment of advanced or recurrent colorectal cancer. The vaccinations were 
      well tolerated without any serious adverse events. There were long-term survivors 
      in the group showing cytotoxic T lymphocyte (CTL) responses against both RNF43 
      and TOMM34, as well as in the group showing CTL responses against either RNF43 or 
      TOMM34. A new study has been planned to obtain more immunological responses. We 
      started a clinical trial of vaccines against multiple peptides (RNF43, TOMM34, 
      forkhead box protein M1 [FOXM1], maternal embryonic leucine zipper kinase [MELK], 
      holliday junction recognition protein[HJURP], vascular endothelial growth factor 
      receptor 1[VEGFR1], and VEGFR2) for the treatment of advanced or recurrent 
      colorectal cancer.
FAU - Sugiura, Fumiaki
AU  - Sugiura F
AD  - Dept. of Surgery, Kinki University Faculty of Medicine.
FAU - Inoue, Keisuke
AU  - Inoue K
FAU - Kogita, Akihiro
AU  - Kogita A
FAU - Yoshioka, Yasumasa
AU  - Yoshioka Y
FAU - Hida, Jinichi
AU  - Hida J
FAU - Okuno, Kiyotaka
AU  - Okuno K
FAU - Sukegawa, Yasushi
AU  - Sukegawa Y
LA  - jpn
PT  - Controlled Clinical Trial
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0 (Cancer Vaccines)
RN  - 0 (Vaccines, Subunit)
RN  - 1548R74NSZ (Tegafur)
RN  - 56HH86ZVCT (Uracil)
RN  - Q573I9DVLP (Leucovorin)
RN  - 1-UFT protocol
SB  - IM
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/administration & 
      dosage/*therapeutic use
MH  - Cancer Vaccines/immunology/*therapeutic use
MH  - Colorectal Neoplasms/*drug therapy/immunology/pathology
MH  - Female
MH  - Humans
MH  - Leucovorin/administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Tegafur/administration & dosage
MH  - Treatment Outcome
MH  - Uracil/administration & dosage
MH  - Vaccines, Subunit/immunology/therapeutic use
EDAT- 2014/01/08 06:00
MHDA- 2014/03/13 06:00
CRDT- 2014/01/08 06:00
PHST- 2014/01/08 06:00 [entrez]
PHST- 2014/01/08 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 2013 Nov;40(12):1584-6.