PMID- 24394906 OWN - NLM STAT- MEDLINE DCOM- 20141007 LR - 20140210 IS - 1872-7972 (Electronic) IS - 0304-3940 (Linking) VI - 561 DP - 2014 Feb 21 TI - BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease. PG - 86-90 LID - S0304-3940(13)01132-4 [pii] LID - 10.1016/j.neulet.2013.12.051 [doi] AB - Brain-derived neurotrophic factor (BDNF) is a neurotrophin widely expressed in the mammalian brain, regulating neuronal survival and known to influence dopaminergic neurons and cognitive processes. The present study investigated the BDNF Val66Met polymorphism associations with PD risk, and cognitive impairment in PD. A total of 486 study subjects (244 PD and 242 age and sex matched controls) were included in the study. UPDRS score, Hoehn-Yahr staging and the Schwab-England scale were used to assess motor abilities and activity during daily life. The patients were classified into groups with dementia (PDD, n=69) and without it (nPDD, n=166) on the basis of neuropsychological assessment. The most common functional polymorphism in BDNF Val66Met (rs6265, G196A) gene was determined using TaqMan real-time PCR assay. Frequencies of evaluated BDNF alleles and genotypes were similar in PD and the controls. The mean age of disease onset among BDNF Met/Met carriers was later (65.00+/-6.13) in comparison to Val/Val (57.45+/-10.68) and Val/Met (56.33+/-10.91) subjects (p=0.077). The studied BDNF polymorphism was not associated with cognitive status in PD patients. However, patients with Met/Met alleles demonstrated better delayed recall of information than patients with Val/Val alleles. The results of multivariate logistic regression analysis revealed age (p=0.0003) and the disease stage (p=0.002) as independent risk factors predisposing to PD dementia. CI - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved. FAU - Bialecka, Monika AU - Bialecka M AD - Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70-111 Szczecin, Poland. Electronic address: monika-bialecka@post.pl. FAU - Kurzawski, Mateusz AU - Kurzawski M AD - Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70-111 Szczecin, Poland. Electronic address: mkurz@pum.edu.pl. FAU - Roszmann, Anna AU - Roszmann A AD - Department of Neurological-Psychiatric Nursing, Medical University of Gdansk, Al. Jana Pawla II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawla II 50, 80-462 Gdansk, Poland. Electronic address: annaroszmann@gmail.com. FAU - Robowski, Piotr AU - Robowski P AD - Department of Neurological-Psychiatric Nursing, Medical University of Gdansk, Al. Jana Pawla II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawla II 50, 80-462 Gdansk, Poland. Electronic address: piotr.amg@wp.pl. FAU - Sitek, Emilia J AU - Sitek EJ AD - Department of Neurological-Psychiatric Nursing, Medical University of Gdansk, Al. Jana Pawla II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawla II 50, 80-462 Gdansk, Poland. Electronic address: emsitek@gmail.com. FAU - Honczarenko, Krystyna AU - Honczarenko K AD - Clinic of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-251 Szczecin, Poland. Electronic address: khonczar@pum.edu.pl. FAU - Mak, Monika AU - Mak M AD - Clinic of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland. Electronic address: monika.mak@gmail.com. FAU - Deptula-Jarosz, Monika AU - Deptula-Jarosz M AD - Department of Neurology, Marie Curie Regional Hospital, Arkonska 4, 71-455 Szczecin, Poland. Electronic address: jaroszki@interia.pl. FAU - Golab-Janowska, Monika AU - Golab-Janowska M AD - Clinic of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-251 Szczecin, Poland. Electronic address: monikagj@op.pl. FAU - Drozdzik, Marek AU - Drozdzik M AD - Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70-111 Szczecin, Poland. Electronic address: drozdzik@pum.edu.pl. FAU - Slawek, Jaroslaw AU - Slawek J AD - Department of Neurological-Psychiatric Nursing, Medical University of Gdansk, Al. Jana Pawla II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawla II 50, 80-462 Gdansk, Poland. Electronic address: jaroslawek@gumed.edu.pl. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140103 PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Brain-Derived Neurotrophic Factor/*genetics MH - Case-Control Studies MH - Cognition Disorders/*genetics MH - Female MH - Genetic Association Studies MH - Genetic Predisposition to Disease MH - Humans MH - Male MH - Middle Aged MH - Parkinson Disease/*genetics/psychology MH - Polymorphism, Genetic OTO - NOTNLM OT - BDNF OT - Dementia OT - Genetic polymorphism OT - Parkinson's disease EDAT- 2014/01/08 06:00 MHDA- 2014/10/08 06:00 CRDT- 2014/01/08 06:00 PHST- 2013/08/13 00:00 [received] PHST- 2013/11/25 00:00 [revised] PHST- 2013/12/21 00:00 [accepted] PHST- 2014/01/08 06:00 [entrez] PHST- 2014/01/08 06:00 [pubmed] PHST- 2014/10/08 06:00 [medline] AID - S0304-3940(13)01132-4 [pii] AID - 10.1016/j.neulet.2013.12.051 [doi] PST - ppublish SO - Neurosci Lett. 2014 Feb 21;561:86-90. doi: 10.1016/j.neulet.2013.12.051. Epub 2014 Jan 3.