PMID- 24395372
OWN - NLM
STAT- MEDLINE
DCOM- 20150202
LR  - 20140701
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 94
IP  - 11
DP  - 2014 Aug
TI  - Murraya koenigii (L.) Spreng. ameliorates insulin resistance in 
      dexamethasone-treated mice by enhancing peripheral insulin sensitivity.
PG  - 2282-8
LID - 10.1002/jsfa.6555 [doi]
AB  - BACKGROUND: Murraya koenigii (L.) Spreng. is an important medicinal plant used 
      traditionally as an antiemetic, antidiarrhoeal agent and blood purifier and as a 
      medicine for a variety of ailments. This study investigated the effects of 
      ethanolic extract of M. koenigii (MK) on diabetes-associated insulin resistance 
      induced in mice by chronic low-dose injection of dexamethasone. RESULTS: Mice 
      treated with dexamethasone exhibited hyperglycaemia and impaired glucose 
      tolerance. Treatment with MK reduced the extent of dexamethasone-induced 
      hyperglycaemia and decreased insulin resistance as indicated by improved glucose 
      tolerance and increased insulin-stimulated AKT phosphorylation in skeletal muscle 
      tissue. Further evaluation in clonal skeletal muscle cell lines suggested that MK 
      increased glucose uptake in L6 skeletal muscle cells by increasing cell surface 
      GLUT4 density via an AKT-mediated pathway. CONCLUSION: MK can ameliorate 
      dexamethasone-induced hyperglycaemia and insulin resistance in part by increasing 
      glucose disposal into skeletal muscle.
CI  - (c) 2014 Society of Chemical Industry.
FAU - Pandey, Jyotsana
AU  - Pandey J
AD  - Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, 226001, 
      India.
FAU - Maurya, Ranjani
AU  - Maurya R
FAU - Raykhera, Rahul
AU  - Raykhera R
FAU - Srivastava, Mahendra N
AU  - Srivastava MN
FAU - Yadav, Prem P
AU  - Yadav PP
FAU - Tamrakar, Akhilesh K
AU  - Tamrakar AK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140213
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - 0 (Blood Glucose)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Insulin)
RN  - 0 (Plant Extracts)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Dexamethasone
MH  - Glucose Intolerance/blood/chemically induced/*drug therapy
MH  - Glucose Transporter Type 4/metabolism
MH  - Hyperglycemia/blood/chemically induced/*drug therapy
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Male
MH  - Mice
MH  - *Murraya
MH  - Muscle Fibers, Skeletal/*drug effects/metabolism
MH  - Phosphorylation
MH  - *Phytotherapy
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - Plant Leaves
MH  - Proto-Oncogene Proteins c-akt/metabolism
OTO - NOTNLM
OT  - Murraya koenigii
OT  - dexamethasone
OT  - glucose uptake
OT  - insulin resistance
EDAT- 2014/01/08 06:00
MHDA- 2015/02/03 06:00
CRDT- 2014/01/08 06:00
PHST- 2013/08/21 00:00 [received]
PHST- 2013/11/19 00:00 [revised]
PHST- 2014/01/06 00:00 [accepted]
PHST- 2014/01/08 06:00 [entrez]
PHST- 2014/01/08 06:00 [pubmed]
PHST- 2015/02/03 06:00 [medline]
AID - 10.1002/jsfa.6555 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2014 Aug;94(11):2282-8. doi: 10.1002/jsfa.6555. Epub 2014 Feb 
      13.