PMID- 24395497
OWN - NLM
STAT- MEDLINE
DCOM- 20141014
LR  - 20211021
IS  - 1937-5395 (Electronic)
IS  - 1937-5387 (Linking)
VI  - 7
IP  - 1
DP  - 2014 Feb
TI  - Scientific foundation and possible implications for practice of the Minimizing 
      Adverse Haemorrhagic Events by Transradial Access Site andSystemic Implementation 
      of AngioX (MATRIX) trial.
PG  - 101-11
LID - 10.1007/s12265-013-9537-1 [doi]
AB  - Early invasive management and the use of combined antithrombotic therapies have 
      decreased the risk of recurrent ischaemia in patients with acute coronary 
      syndrome (ACS) but have also increased the bleeding risk. Transradial 
      intervention (TRI) and bivalirudin infusion compared to transfemoral intervention 
      (TFI) or unfractionated heparin (UFH) plus glycoprotein IIb/IIIa inhibitors (GPI) 
      decrease bleeding complications in patients with ACS. To what extent, a bleeding 
      preventive strategy incorporating at least one of these two treatment options 
      translates into improved outcomes is a matter of debate. The Minimizing Adverse 
      Haemorrhagic Events by Transradial Access Site and Systemic Implementation of 
      AngioX study is a large-scale, multicenter, prospective, open-label trial, 
      conducted at approximately 100 sites in Europe aiming to primarily assess whether 
      TRI and bivalirudin infusion, as compared to TFI and UFH plus provisional GPI, 
      decrease the 30-day incidence of death, myocardial infarction or stroke across 
      the whole spectrum of ACS patients.
FAU - Valgimigli, Marco
AU  - Valgimigli M
AD  - Thoraxcenter, Ba 587, Erasmus MC, Rotterdam, The Netherlands, 
      m.valgimigli@erasmusmc.nl.
FAU - Calabro, Paolo
AU  - Calabro P
FAU - Cortese, Bernardo
AU  - Cortese B
FAU - Frigoli, Enrico
AU  - Frigoli E
FAU - Garducci, Stefano
AU  - Garducci S
FAU - Rubartelli, Paolo
AU  - Rubartelli P
FAU - Ando, Giuseppe
AU  - Ando G
FAU - Santarelli, Andrea
AU  - Santarelli A
FAU - Galli, Mario
AU  - Galli M
FAU - Garbo, Roberto
AU  - Garbo R
FAU - Repetto, Alessandra
AU  - Repetto A
FAU - Ierna, Salvatore
AU  - Ierna S
FAU - Briguori, Carlo
AU  - Briguori C
FAU - Limbruno, Ugo
AU  - Limbruno U
FAU - Violini, Roberto
AU  - Violini R
FAU - Gagnor, Andrea
AU  - Gagnor A
CN  - MATRIX investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT01433627
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140107
PL  - United States
TA  - J Cardiovasc Transl Res
JT  - Journal of cardiovascular translational research
JID - 101468585
RN  - 0 (Anticoagulants)
RN  - 0 (Antithrombins)
RN  - 0 (Hirudins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Platelet Glycoprotein GPIIb-IIIa Complex)
RN  - 0 (Recombinant Proteins)
RN  - 9005-49-6 (Heparin)
RN  - TN9BEX005G (bivalirudin)
SB  - IM
MH  - Acute Coronary Syndrome/blood/diagnosis/mortality/*therapy
MH  - Anticoagulants/*administration & dosage/adverse effects
MH  - Antithrombins/*administration & dosage/adverse effects
MH  - Clinical Protocols
MH  - Drug Therapy, Combination
MH  - Europe
MH  - *Femoral Artery
MH  - Hemorrhage/chemically induced/mortality/*prevention & control
MH  - Heparin/administration & dosage/adverse effects
MH  - Hirudins/administration & dosage/adverse effects
MH  - Humans
MH  - Peptide Fragments/administration & dosage/adverse effects
MH  - Percutaneous Coronary Intervention/adverse effects/*methods/mortality
MH  - Platelet Aggregation Inhibitors/*administration & dosage/adverse effects
MH  - Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors/metabolism
MH  - Prospective Studies
MH  - Punctures
MH  - *Radial Artery
MH  - Recombinant Proteins/administration & dosage/adverse effects
MH  - *Research Design
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2014/01/08 06:00
MHDA- 2014/10/15 06:00
CRDT- 2014/01/08 06:00
PHST- 2013/11/09 00:00 [received]
PHST- 2013/12/13 00:00 [accepted]
PHST- 2014/01/08 06:00 [entrez]
PHST- 2014/01/08 06:00 [pubmed]
PHST- 2014/10/15 06:00 [medline]
AID - 10.1007/s12265-013-9537-1 [doi]
PST - ppublish
SO  - J Cardiovasc Transl Res. 2014 Feb;7(1):101-11. doi: 10.1007/s12265-013-9537-1. 
      Epub 2014 Jan 7.