PMID- 24396280
OWN - NLM
STAT- MEDLINE
DCOM- 20140930
LR  - 20220311
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 11
IP  - 1
DP  - 2014
TI  - Influence of endodontic treatment on systemic oxidative stress.
PG  - 1-6
LID - 10.7150/ijms.6663 [doi]
AB  - INTRODUCTION: An increased production of oxidizing species related to reactive 
      oral diseases, such as chronic apical periodontitis, could have systemic 
      implications such as an increase in cardiovascular morbidity. Based on this 
      consideration, we conducted a prospective study to assess whether subjects 
      affected by chronic periodontitis presented with higher values of oxidative 
      stress than reference values before endodontic treatment, and whether endodontic 
      treatment can reduce the oxidative imbalance and bring it back to normal in these 
      subjects. MATERIALS AND METHODS: The authors recruited 2 groups of patients from 
      private studies and dental clinics: these patients were recruited randomly. The 
      oxidative balance in both patients with chronic apical periodontitis (CAP) and 
      healthy control patients was determined by measuring the oxidant status, using an 
      identification of the reactive oxygen metabolites (d-ROMs) test, while the 
      antioxidant status in these patients was determined using a biological 
      antioxidant potential (BAP) test. Both these tests were carried on plasma samples 
      taken from enrolled patients. Values were measured both before the endodontic 
      treatment of the patients with chronic apical periodontitis, and 30 and 90 days 
      after treatment, and compared to those obtained from healthy control patients. 
      RESULTS: It was found that, on recruitment, the patients with chronic apical 
      periodontitis exhibited significantly higher levels of oxidative stress than 
      control patients, as determined by the d-ROMs and BAP tests. Furthermore, the 
      d-ROMs test values were shown to decrease and the BAP test values to increase 
      over time in patients with chronic apical periodontitis following endodontic 
      therapy. As the levels of oxidative stress in these patients tended to reduce and 
      return to normal by 90 days following treatment. CONCLUSIONS: This study has 
      demonstrated a positive association between chronic apical periodontitis and 
      oxidative stress. Subjects affected by chronic apical periodontitis are exposed 
      to a condition of oxidative stress, which is extremely dangerous to general 
      health. Moreover, one can infer from these findings that through proper 
      endodontic therapy, a good oxidative balance can be restored, thereby avoiding 
      the risk of contracting the abovementioned diseases.
FAU - Inchingolo, Francesco
AU  - Inchingolo F
AD  - 1. Department of interdisciplinary Medicine, University of Bari, General 
      Hospital, Bari, Italy;
FAU - Marrelli, Massimo
AU  - Marrelli M
AD  - 2. Unit of Maxillofacial Surgery, Calabrodental, Crotone, Italy; ; 4. Tecnologica 
      Research Institute, Biomedical Section, Crotone, Italy;
FAU - Annibali, Susanna
AU  - Annibali S
AD  - 6. Department of Stomatology and Maxillofacial Science - Oral Surgery Unit - 
      University of Rome "Sapienza" Rome, Italy;
FAU - Cristalli, Maria Paola
AU  - Cristalli MP
AD  - 6. Department of Stomatology and Maxillofacial Science - Oral Surgery Unit - 
      University of Rome "Sapienza" Rome, Italy;
FAU - Dipalma, Gianna
AU  - Dipalma G
AD  - 2. Unit of Maxillofacial Surgery, Calabrodental, Crotone, Italy;
FAU - Inchingolo, Alessio Danilo
AU  - Inchingolo AD
AD  - 7. Medical School, University of Bari, Bari, Italy;
FAU - Palladino, Antonio
AU  - Palladino A
AD  - 7. Medical School, University of Bari, Bari, Italy;
FAU - Inchingolo, Angelo Michele
AU  - Inchingolo AM
AD  - 5. Department of Surgical, Reconstructive, and Diagnostic Sciences, University of 
      Milan, Milan, Italy;
FAU - Gargari, Marco
AU  - Gargari M
AD  - 8. Department of Clinical Sciences and Translational Medicine, University of Rome 
      "Tor Vergata", Rome, Italy.
FAU - Tatullo, Marco
AU  - Tatullo M
AD  - 2. Unit of Maxillofacial Surgery, Calabrodental, Crotone, Italy; ; 3. Department 
      of Basic Medical Sciences, University of Bari, Bari, Italy; ; 4. Tecnologica 
      Research Institute, Biomedical Section, Crotone, Italy;
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20131206
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antioxidants/analysis/metabolism
MH  - Chronic Periodontitis/*metabolism/*therapy
MH  - Endodontics/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Periapical Periodontitis/*metabolism/*therapy
MH  - Prospective Studies
MH  - Reactive Oxygen Species/blood
MH  - Treatment Outcome
PMC - PMC3880985
OTO - NOTNLM
OT  - Oxidative stress
OT  - chronic apical periodontitis
OT  - endodontic treatment.
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2014/01/08 06:00
MHDA- 2014/10/01 06:00
PMCR- 2014/01/01
CRDT- 2014/01/08 06:00
PHST- 2013/05/09 00:00 [received]
PHST- 2013/08/26 00:00 [accepted]
PHST- 2014/01/08 06:00 [entrez]
PHST- 2014/01/08 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - ijmsv11p0001 [pii]
AID - 10.7150/ijms.6663 [doi]
PST - epublish
SO  - Int J Med Sci. 2013 Dec 6;11(1):1-6. doi: 10.7150/ijms.6663. eCollection 2014.