PMID- 24397396
OWN - NLM
STAT- MEDLINE
DCOM- 20141208
LR  - 20140321
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 30
IP  - 4
DP  - 2014 Apr
TI  - Bisphenol A (BPA) and its potential role in the pathogenesis of the polycystic 
      ovary syndrome (PCOS).
PG  - 260-5
LID - 10.3109/09513590.2013.871517 [doi]
AB  - Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous 
      endocrine disorder in premenopausal women. Apart from signs of hyperandrogenism 
      such as acne, hirsutism and hair loss, women with PCOS usually present with 
      menstrual irregularities and fertility problems.Additionally, they are often 
      characterized by impaired glucose tolerance, which usually leads to the 
      development of type 2 diabetes mellitus (T2DM). This review article describes 
      current and novel approach to the pathomechanisms of PCOS and the potential role 
      of an endocrine disrupting chemical ("endocrine disruptor" - ED) - bisphenol A 
      (BPA), which is commonly used as a plasticizer and due to its molecular structure 
      can interact with estrogen receptors (ERs). Recent observations point to the 
      higher levels of BPA in biological fluids of women with PCOS and its role in the 
      pathogenesis of hyperandrogenism and hyperinsulinemia. It seems that mother's 
      exposure to BPA during pregnancy may also lead to the development of PCOS in the 
      female offspring.
FAU - Rutkowska, Aleksandra
AU  - Rutkowska A
AD  - Department of Clinical and Experimental Endocrinology, Institute of Maritime and 
      Tropical Medicine, Medical University of Gdansk , Gdynia , Poland.
FAU - Rachon, Dominik
AU  - Rachon D
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140107
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds/*poisoning/toxicity
MH  - Endocrine Disruptors/*poisoning/toxicity
MH  - Female
MH  - Humans
MH  - Phenols/*poisoning/toxicity
MH  - Polycystic Ovary Syndrome/*chemically induced/pathology
MH  - Pregnancy
EDAT- 2014/01/09 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/09 06:00
PHST- 2014/01/09 06:00 [entrez]
PHST- 2014/01/09 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.3109/09513590.2013.871517 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2014 Apr;30(4):260-5. doi: 10.3109/09513590.2013.871517. Epub 
      2014 Jan 7.