PMID- 24397488
OWN - NLM
STAT- MEDLINE
DCOM- 20140908
LR  - 20220330
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 83
IP  - 2
DP  - 2014 Feb
TI  - HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in 
      Kazakhstan.
PG  - 106-12
LID - 10.1111/tan.12279 [doi]
AB  - The human leukocyte antigen (HLA) system has a major role in the regulation of 
      the immune response as it is involved in the defense against pathogens. Some 
      studies have reported that HLA class II genes play a strong role in severe cases 
      of pulmonary tuberculosis (PTB) in several populations. Thus the aim of the study 
      was to compare the HLA-class II alleles of patients with drug resistant 
      tuberculosis with those of healthy controls from the same ethnic group in 
      Kazakhstan. The aim of the present study was to evaluate the correlation of 
      HLA-class II alleles by patients with drug resistant tuberculosis and the healthy 
      controls of the same ethnic group in Kazakhstan. The HLA-class II alleles of 76 
      patients with tuberculosis (TB) and 157 healthy volunteers were investigated 
      using sequence-based typing (SBT)-method. HLA-DQA1*03:02 HLA-DRB1*08:01 and 
      DRB1*08:03 occurred more frequently (P = 0.05) in patients with drug resistant 
      tuberculosis than in controls. We observed a possible association between certain 
      HLA alleles and TB that are specific for the Kazakh population. Further studies 
      are needed to confirm our findings using a larger number of patients with drug 
      resistant tuberculosis.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Kuranov, A B
AU  - Kuranov AB
AD  - National Center for Biotechnology, Astana, Kazakhstan.
FAU - Kozhamkulov, U A
AU  - Kozhamkulov UA
FAU - Vavilov, M N
AU  - Vavilov MN
FAU - Belova, E S
AU  - Belova ES
FAU - Bismilda, V L
AU  - Bismilda VL
FAU - Alenova, A H
AU  - Alenova AH
FAU - Ismailov, S S
AU  - Ismailov SS
FAU - Momynaliev, K T
AU  - Momynaliev KT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140107
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antitubercular Agents)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Antitubercular Agents/therapeutic use
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ alpha-Chains/classification/*genetics/immunology
MH  - HLA-DRB1 Chains/classification/*genetics/immunology
MH  - *Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kazakhstan
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium tuberculosis/drug effects/immunology
MH  - Tuberculosis, Multidrug-Resistant/drug therapy/*genetics/immunology/microbiology
MH  - Tuberculosis, Pulmonary/drug therapy/*genetics/immunology/microbiology
OTO - NOTNLM
OT  - Kazakhstan
OT  - human leukocyte antigen
OT  - tuberculosis
EDAT- 2014/01/09 06:00
MHDA- 2014/09/10 06:00
CRDT- 2014/01/09 06:00
PHST- 2013/07/30 00:00 [received]
PHST- 2013/11/14 00:00 [revised]
PHST- 2013/12/02 00:00 [accepted]
PHST- 2014/01/09 06:00 [entrez]
PHST- 2014/01/09 06:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
AID - 10.1111/tan.12279 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Feb;83(2):106-12. doi: 10.1111/tan.12279. Epub 2014 Jan 7.