PMID- 24397734
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140110
LR  - 20211021
IS  - 1476-9255 (Print)
IS  - 1476-9255 (Electronic)
IS  - 1476-9255 (Linking)
VI  - 11
IP  - 1
DP  - 2014 Jan 7
TI  - A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted 
      factors in the treatment of systemic inflammation.
PG  - 1
LID - 10.1186/1476-9255-11-1 [doi]
AB  - BACKGROUND: Bone marrow-derived mesenchymal stromal cells (BMSCs) are a cell 
      population of intense exploration for therapeutic use in inflammatory diseases. 
      Secreted factors released by BMSCs are responsible for the resolution of 
      inflammation in several pre-clinical models. New studies have uncovered that 
      adipose tissue also serves as a reservoir of multipotent, non-hematopoietic stem 
      cells, termed adipose-derived stromal/stem cells (ASCs), with many common 
      characteristics to BMSCs. We hypothesized that ASC and BMSC secreted factors 
      would lead to a comparable benefit in the context of generalized inflammation. 
      FINDINGS: Proteomic profiling of conditioned media revealed that BMSCs express 
      significantly higher levels of sVEGFR1 and sTNFR1, two soluble cytokine receptors 
      with known therapeutic activity in sepsis. In a prophylactic study of 
      endotoxin-induced inflammation in mice, we observed that BMSC secreted factors 
      provided a greater survival benefit and tissue protection of endotoxemic mice 
      compared to ASCs. Neutralization of sVEGFR1 and sTNFR1 did not significantly 
      affect the survival benefit experienced by mice treated with BMSC secreted 
      factors. CONCLUSIONS: Our findings suggest that BMSCs may be more effective as a 
      cell therapeutic for use in endotoxic shock and that ASCs may be positioned for 
      continued exploration in immunomodulatory diseases. Soluble cytokine receptors 
      can distinguish stromal cells from different tissue origins, though they may not 
      be the sole contributors to the therapeutic benefit of BMSCs. Furthermore, other 
      secreted factors not discussed in this study may also differentiate these stromal 
      cell populations from one another.
FAU - Elman, Jessica S
AU  - Elman JS
FAU - Li, Matthew
AU  - Li M
FAU - Wang, Fangjing
AU  - Wang F
FAU - Gimble, Jeffrey M
AU  - Gimble JM
FAU - Parekkadan, Biju
AU  - Parekkadan B
AD  - Center for Engineering in Medicine and Surgical Services, Massachusetts General 
      Hospital, Harvard Medical School and Shriners Hospital for Children in Boston, 
      Boston, MA 02114, USA. biju_parekkadan@hms.harvard.edu.
LA  - eng
GR  - K01 DK087770/DK/NIDDK NIH HHS/United States
GR  - R01 EB012521/EB/NIBIB NIH HHS/United States
PT  - Journal Article
DEP - 20140107
PL  - England
TA  - J Inflamm (Lond)
JT  - Journal of inflammation (London, England)
JID - 101232234
PMC - PMC3895743
EDAT- 2014/01/09 06:00
MHDA- 2014/01/09 06:01
PMCR- 2014/01/07
CRDT- 2014/01/09 06:00
PHST- 2012/11/20 00:00 [received]
PHST- 2013/12/06 00:00 [accepted]
PHST- 2014/01/09 06:00 [entrez]
PHST- 2014/01/09 06:00 [pubmed]
PHST- 2014/01/09 06:01 [medline]
PHST- 2014/01/07 00:00 [pmc-release]
AID - 1476-9255-11-1 [pii]
AID - 10.1186/1476-9255-11-1 [doi]
PST - epublish
SO  - J Inflamm (Lond). 2014 Jan 7;11(1):1. doi: 10.1186/1476-9255-11-1.