PMID- 24398043
OWN - NLM
STAT- MEDLINE
DCOM- 20140520
LR  - 20211021
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Print)
IS  - 0165-0327 (Linking)
VI  - 156
DP  - 2014 Mar
TI  - Blood levels of brain derived neurotrophic factor in women with bipolar disorder 
      and healthy control women.
PG  - 214-8
LID - S0165-0327(13)00836-7 [pii]
LID - 10.1016/j.jad.2013.01.054 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) protein has been implicated 
      in the pathophysiology of mood disorders, with early data suggesting that blood 
      levels may vary by severity of mood symptoms. BDNF polymorphism, val66met, has 
      also been implicated in mood disorders. METHODS: Euthymic women with bipolar 
      disorder (BD) (n=47) and healthy control women (n=26), ages 18-45, were 
      clinically rated using the Montgomery-Asberg Depression Rating Scale (MADRS) and 
      sampled for plasma BDNF concentration, with a subset undergoing genetic analysis 
      for the val66met. RESULTS: BD and control groups did not differ on any 
      demographic variables, nor in plasma BDNF levels or val66met polymorphism. Plasma 
      BDNF concentration did not differ by val66met or BD subtype, nor was it 
      correlated with age or illness duration. Within women with BD, lower plasma BDNF 
      concentrations were significantly associated with higher MADRS scores, even after 
      controlling for psychotropic medication use and illness duration. LIMITATIONS: 
      The sample was relatively small and exclusive to women, with further research 
      needed to investigate the links between BDNF markers and mood symptom severity in 
      both men and women. CONCLUSIONS: The study provides a gender-specific 
      investigation of plasma BDNF levels and mood, and the results add further 
      evidence of a significant interplay between BDNF markers and psychiatric 
      symptomatology. Further, this association did not appear to be confounded by use 
      of psychotropic medication. Studies with larger samples of both genders are 
      needed to further delineate this relationship.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Kenna, Heather A
AU  - Kenna HA
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, 401 Quarry Rd MC 5723, Stanford, CA 94305-5723, United States.
FAU - Reynolds-May, Margaret
AU  - Reynolds-May M
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, 401 Quarry Rd MC 5723, Stanford, CA 94305-5723, United States.
FAU - Stepanenko, Aleksandra
AU  - Stepanenko A
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, 401 Quarry Rd MC 5723, Stanford, CA 94305-5723, United States.
FAU - Ketter, Terence A
AU  - Ketter TA
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, 401 Quarry Rd MC 5723, Stanford, CA 94305-5723, United States.
FAU - Hallmayer, Joachim
AU  - Hallmayer J
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, 401 Quarry Rd MC 5723, Stanford, CA 94305-5723, United States.
FAU - Rasgon, Natalie L
AU  - Rasgon NL
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, 401 Quarry Rd MC 5723, Stanford, CA 94305-5723, United States. 
      Electronic address: nrasgon@stanford.edu.
LA  - eng
GR  - M01 RR000070/RR/NCRR NIH HHS/United States
GR  - R01 MH066033/MH/NIMH NIH HHS/United States
GR  - M01RR-00070/RR/NCRR NIH HHS/United States
GR  - MH066033/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131221
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bipolar Disorder/*blood/*genetics
MH  - Brain-Derived Neurotrophic Factor/*blood/*genetics
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Young Adult
PMC - PMC3940211
MID - NIHMS553519
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Brain-derived neurotrophic factor
OT  - Depressive symptomatology
OT  - Val66met
OT  - Women
EDAT- 2014/01/09 06:00
MHDA- 2014/05/21 06:00
PMCR- 2015/03/01
CRDT- 2014/01/09 06:00
PHST- 2013/01/25 00:00 [received]
PHST- 2013/01/30 00:00 [accepted]
PHST- 2014/01/09 06:00 [entrez]
PHST- 2014/01/09 06:00 [pubmed]
PHST- 2014/05/21 06:00 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - S0165-0327(13)00836-7 [pii]
AID - 10.1016/j.jad.2013.01.054 [doi]
PST - ppublish
SO  - J Affect Disord. 2014 Mar;156:214-8. doi: 10.1016/j.jad.2013.01.054. Epub 2013 
      Dec 21.