PMID- 24398050
OWN - NLM
STAT- MEDLINE
DCOM- 20141031
LR  - 20240109
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 122
IP  - 3
DP  - 2014 Mar
TI  - Relationships of polychlorinated biphenyls and dichlorodiphenyldichloroethylene 
      (p,p'-DDE) with testosterone levels in adolescent males.
PG  - 304-9
LID - 10.1289/ehp.1205984 [doi]
AB  - BACKGROUND: Concern persists over endocrine-disrupting effects of persistent 
      organic pollutants (POPs) on human growth and sexual maturation. Potential 
      effects of toxicant exposures on testosterone levels during puberty are not well 
      characterized. OBJECTIVES: In this study we evaluated the relationship between 
      toxicants [polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene 
      (p,p -DDE), hexachlorobenzene (HCB), and lead] and testosterone levels among 127 
      Akwesasne Mohawk males 10 to < 17 years of age with documented toxicant 
      exposures. METHODS: Data were collected between February 1996 and January 2000. 
      Fasting blood specimens were collected before breakfast by trained Akwesasne 
      Mohawk staff. Multivariable regression models were used to estimates associations 
      between toxicants and serum testosterone, adjusted for other toxicants, Tanner 
      stage, and potential confounders. RESULTS: The sum of 16 PCB congeners (Sigma16PCBs) 
      that were detected in >/= 50% of the population was significantly and negatively 
      associated with serum testosterone levels, such that a 10% change in exposure was 
      associated with a 5.6% decrease in testosterone (95% CI: -10.8, -0.5%). Of the 16 
      congeners, the more persistent ones (Sigma8PerPCBs) were related to testosterone, 
      whereas the less persistent ones, possibly reflecting more recent exposure, were 
      not. When PCB congeners were subgrouped, the association was significant for the 
      sum of eight more persistent PCBs (5.7% decrease; 95% CI: -11, -0.4%), and 
      stronger than the sum of six less persistent congeners (3.1% decrease; 95% CI: 
      -7.2, 0.9%). p,p -DDE was positively but not significantly associated with serum 
      testosterone (5.2% increase with a 10% increase in exposure; 95% CI: -0.5, 
      10.9%). Neither lead nor HCB was significantly associated with testosterone 
      levels. CONCLUSIONS: Exposure to PCBs, particularly the more highly persistent 
      congeners, may negatively influence testosterone levels among adolescent males. 
      The positive relationship between p,p -DDE and testosterone indicates that not 
      all POPs act similarly. CITATION: Schell LM, Gallo MV, Deane GD, Nelder KR, 
      DeCaprio AP, Jacobs A; Akwesasne Task Force on the Environment. 2014. 
      Relationships of polychlorinated biphenyls and dichlorodiphenyldichloroethylene 
      (p,p -DDE) with testosterone levels in adolescent males. Environ Health Perspect 
      122:304-309; http://dx.doi.org/10.1289/ehp.1205984.
FAU - Schell, Lawrence M
AU  - Schell LM
AD  - Center for the Elimination of Minority Health Disparities, and.
FAU - Gallo, Mia V
AU  - Gallo MV
FAU - Deane, Glenn D
AU  - Deane GD
FAU - Nelder, Kyrie R
AU  - Nelder KR
FAU - DeCaprio, Anthony P
AU  - DeCaprio AP
FAU - Jacobs, Agnes
AU  - Jacobs A
CN  - Akwesasne Task Force on the Environment
LA  - eng
GR  - P20 MD003373/MD/NIMHD NIH HHS/United States
GR  - ES10904/ES/NIEHS NIH HHS/United States
GR  - R01 ES010904/ES/NIEHS NIH HHS/United States
GR  - ESO4913/PHS HHS/United States
GR  - 1 P20 MD003373/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131220
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 2P299V784P (Lead)
RN  - 3XMK78S47O (Testosterone)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Environmental Exposure
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Lead/blood
MH  - Male
MH  - Multivariate Analysis
MH  - New York
MH  - Polychlorinated Biphenyls/*blood
MH  - Regression Analysis
MH  - Spectrophotometry, Atomic
MH  - Testosterone/*blood
PMC - PMC3948020
COIS- The content is solely the responsibility of the authors and does not represent 
      the official views of the National Institute on Minority Health and Health 
      Disparities or the National Institutes of Health. Members of the Akwesasne 
      community have been involved in a lawsuit against a local industry that has 
      contributed to the pollution of the St. Lawrence River and/or its tributaries. 
      Some of these members are related to the authors who are members of the community 
      (A.J. and the Akwesasne Task Force on the Environment). The authors declare they 
      have no actual or potential competing financial interests.
EDAT- 2014/01/09 06:00
MHDA- 2014/11/02 06:00
PMCR- 2014/03/01
CRDT- 2014/01/09 06:00
PHST- 2012/09/06 00:00 [received]
PHST- 2013/12/20 00:00 [accepted]
PHST- 2014/01/09 06:00 [entrez]
PHST- 2014/01/09 06:00 [pubmed]
PHST- 2014/11/02 06:00 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - ehp.1205984 [pii]
AID - 10.1289/ehp.1205984 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2014 Mar;122(3):304-9. doi: 10.1289/ehp.1205984. Epub 
      2013 Dec 20.