PMID- 24398051
OWN - NLM
STAT- MEDLINE
DCOM- 20141008
LR  - 20140219
IS  - 1527-3326 (Electronic)
IS  - 0926-2040 (Linking)
VI  - 57-58
DP  - 2014 Feb-Apr
TI  - Recent progress in solid-state NMR studies of drugs confined within drug delivery 
      systems.
PG  - 2-16
LID - S0926-2040(13)00092-1 [pii]
LID - 10.1016/j.ssnmr.2013.12.001 [doi]
AB  - Recent progress in the application of solid-state NMR (SS NMR) spectroscopy in 
      structural studies of active pharmaceutical ingredients (APIs) embedded in 
      different drug carriers is detailed. This article is divided into sections. The 
      first part reports short characterization of the nanoparticles and microparticles 
      that can be used as drug delivery systems (DDSs). The second part shows the 
      applicability of SS NMR to study non-steroidal anti-inflammatory drugs (NSAIDs). 
      In this section, problems related to API-DDS interactions, morphology, local 
      molecular dynamics, nature of inter- or intramolecular connections, and pore 
      filling are reviewed for different drug carriers (e.g. mesoporous silica 
      nanoparticles (MSNs), cyclodextrins, polymeric matrices and others). The third 
      and fourth sections detail the recent applications of SS NMR for searching for 
      antibiotics and anticancer drugs confined in zeolites, MSNs, amorphous calcium 
      phosphate and other carriers.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Skorupska, Ewa
AU  - Skorupska E
AD  - Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 
      Sienkiewicza 112, 90-363 Lodz, Poland.
FAU - Jeziorna, Agata
AU  - Jeziorna A
AD  - Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 
      Sienkiewicza 112, 90-363 Lodz, Poland.
FAU - Kazmierski, Slawomir
AU  - Kazmierski S
AD  - Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 
      Sienkiewicza 112, 90-363 Lodz, Poland.
FAU - Potrzebowski, Marek J
AU  - Potrzebowski MJ
AD  - Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 
      Sienkiewicza 112, 90-363 Lodz, Poland. Electronic address: marekpot@cbmm.lodz.pl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131222
PL  - Netherlands
TA  - Solid State Nucl Magn Reson
JT  - Solid state nuclear magnetic resonance
JID - 9306181
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Antifungal Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Anti-Bacterial Agents/chemistry
MH  - Anti-Inflammatory Agents, Non-Steroidal/chemistry
MH  - Antifungal Agents/chemistry
MH  - Drug Carriers/*chemistry
MH  - Humans
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Pharmaceutical Preparations/*chemistry
OTO - NOTNLM
OT  - Antibiotics
OT  - Anticancer drugs
OT  - Drug delivery systems
OT  - Non-steroidal anti-inflammatory drugs
OT  - Solid-state NMR
EDAT- 2014/01/09 06:00
MHDA- 2014/10/09 06:00
CRDT- 2014/01/09 06:00
PHST- 2013/10/01 00:00 [received]
PHST- 2013/11/27 00:00 [revised]
PHST- 2013/12/03 00:00 [accepted]
PHST- 2014/01/09 06:00 [entrez]
PHST- 2014/01/09 06:00 [pubmed]
PHST- 2014/10/09 06:00 [medline]
AID - S0926-2040(13)00092-1 [pii]
AID - 10.1016/j.ssnmr.2013.12.001 [doi]
PST - ppublish
SO  - Solid State Nucl Magn Reson. 2014 Feb-Apr;57-58:2-16. doi: 
      10.1016/j.ssnmr.2013.12.001. Epub 2013 Dec 22.