PMID- 24399456
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220331
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 34
IP  - 8
DP  - 2014 Aug
TI  - Involvement of BDNF in knee osteoarthritis: the relationship with inflammation 
      and clinical parameters.
PG  - 1153-7
LID - 10.1007/s00296-013-2943-5 [doi]
AB  - The aim of this study was to analyze the levels of brain-derived neurotrophic 
      factor (BDNF) in both the plasma and synovial fluid of patients with primary knee 
      osteoarthritis compared with control individuals and to investigate the 
      relationship between BDNF levels and self-reported pain. Twenty-seven patients 
      with knee osteoarthritis (OA) and 19 healthy subjects were enrolled in the study. 
      Anteroposterior knee radiographs were taken to determine the disease severity of 
      the affected knee. Radiographic grading of OA in the knee was performed using the 
      Kellgren-Lawrence criteria. The BDNF levels in the plasma and synovial fluid were 
      measured by enzyme-linked immunosorbent assay. The mean plasma BDNF levels of the 
      knee OA patients were significantly higher than that of the healthy controls 
      (2,378 +/- 1,067.2 vs. 1,756 +/- 804.3 pg/mL, p < 0.05). BDNF levels in the synovial 
      fluid of OA patients (358.9 +/- 178.4 pg/mL) were sixfold lower than in 
      corresponding blood samples (p < 0.0001) and fourfold lower than in the plasma of 
      healthy controls (p < 0.0001). Subsequent analyses showed that the plasma BDNF 
      levels significantly correlated with self-reported pain (Western Ontario and 
      McMaster Universities Osteoarthritis Index) (r s = 0.39, p = 0.04). Furthermore, 
      no correlation was found between the plasma and synovial fluid BDNF 
      concentrations and knee OA severity. The findings of this study suggest that 
      systemic BDNF levels are most likely associated with the mechanism of joint pain 
      in knee OA in the acute stage of joint inflammatory process. Further studies are 
      necessary to address the functional role of BDNF in the modulation of pain to 
      establish new therapeutic implications.
FAU - Simao, Adriano Prado
AU  - Simao AP
AD  - Integrated Center for Graduate Studies and Research Health (CIPq-Health), Federal 
      University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, 
      Brazil, adrianopsimao@ig.com.br.
FAU - Mendonca, Vanessa Amaral
AU  - Mendonca VA
FAU - de Oliveira Almeida, Tassio Malber
AU  - de Oliveira Almeida TM
FAU - Santos, Sergio Antunes
AU  - Santos SA
FAU - Gomes, Wellington Fabiano
AU  - Gomes WF
FAU - Coimbra, Candido Celso
AU  - Coimbra CC
FAU - Lacerda, Ana Cristina Rodrigues
AU  - Lacerda AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140109
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Biomarkers
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Osteoarthritis, Knee/blood/*diagnosis/diagnostic imaging
MH  - Pain Measurement
MH  - Predictive Value of Tests
MH  - Radiography
MH  - Severity of Illness Index
MH  - Synovial Fluid/*chemistry
EDAT- 2014/01/09 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/01/09 06:00
PHST- 2013/10/03 00:00 [received]
PHST- 2013/12/30 00:00 [accepted]
PHST- 2014/01/09 06:00 [entrez]
PHST- 2014/01/09 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1007/s00296-013-2943-5 [doi]
PST - ppublish
SO  - Rheumatol Int. 2014 Aug;34(8):1153-7. doi: 10.1007/s00296-013-2943-5. Epub 2014 
      Jan 9.