PMID- 24399868
OWN - NLM
STAT- MEDLINE
DCOM- 20140221
LR  - 20220331
IS  - 1128-2460 (Print)
IS  - 1128-2460 (Electronic)
IS  - 1128-2460 (Linking)
VI  - 32
IP  - 2
DP  - 2013 Oct
TI  - Hypogonadism and erectile dysfunction in myotonic dystrophy type 1.
PG  - 106-9
AB  - Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in 
      adults. It affects many organs and systems besides muscle. Aim of this study was 
      to assess frequency of erectile dysfunction (ED) and hypogonadism, the 
      correlation between them and the impact of ED on quality of life (QoL) in 
      patients with DM1. A series of 25 men (aged from 22 to 58 years) with a diagnosis 
      of DM1 was analyzed. Muscular Impairment Rating Scale (MIRS) was used to assess 
      severity of muscular involvement. Erectile function was assessed using the short 
      form of the International Index of Erectile Function test (IIEF-5). Levels of 
      follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone 
      were assessed. All patients completed the Serbian version of the SF-36 
      questionnaire as a measure of health-related QoL. ED was present in 18 (72%) of 
      patients. Seven (28%) patients were euogonadic, 16 (64%) had compensated 
      hypogonadism and 2 (8%) had primary hypogonadism. ED was somewhat more common in 
      patients with hypogonadism (78% vs. 57%). Mental composite score of SF-36 was 
      lower in patients with ED (p<0.05). Our results showed that 72% of men with DM1 
      had ED and hypogonadism. Studies with larger number of subjects are needed to 
      resolve cascade of events that lays behind ED in DM1. Development of therapeutic 
      strategies may have positive impact on QoL. Substitutive therapy with androgens 
      may be benefitial.
FAU - Peric, Stojan
AU  - Peric S
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia;
FAU - Nisic, Tanja
AU  - Nisic T
AD  - Institute of Endocrinology, Clinical Center of Serbia, School of Medicine, 
      University of Belgrade, Belgrade, Serbia.
FAU - Milicev, Milena
AU  - Milicev M
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia;
FAU - Basta, Ivana
AU  - Basta I
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia;
FAU - Marjanovic, Ivan
AU  - Marjanovic I
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia;
FAU - Peric, Marina
AU  - Peric M
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia;
FAU - Lavrnic, Dragana
AU  - Lavrnic D
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia;
FAU - Rakocevic Stojanovic, Vidosava
AU  - Rakocevic Stojanovic V
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia;
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Acta Myol
JT  - Acta myologica : myopathies and cardiomyopathies : official journal of the 
      Mediterranean Society of Myology
JID - 9811169
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Demography
MH  - *Erectile Dysfunction/etiology/psychology
MH  - Humans
MH  - *Hypogonadism/blood/etiology
MH  - Male
MH  - Middle Aged
MH  - *Muscle Hypotonia/etiology/physiopathology
MH  - *Myotonic Dystrophy/complications/epidemiology/physiopathology
MH  - Quality of Life
MH  - Serbia/epidemiology
MH  - Severity of Illness Index
MH  - Statistics as Topic
MH  - Testosterone/blood
PMC - PMC3866901
OTO - NOTNLM
OT  - erectile dysfunction
OT  - hypogonadis
OT  - myotonic dystrophy type 1
EDAT- 2014/01/09 06:00
MHDA- 2014/02/22 06:00
PMCR- 2013/10/01
CRDT- 2014/01/09 06:00
PHST- 2014/01/09 06:00 [entrez]
PHST- 2014/01/09 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - Pacini [pii]
PST - ppublish
SO  - Acta Myol. 2013 Oct;32(2):106-9.