PMID- 24399882
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140108
LR  - 20211021
IS  - 1178-7031 (Print)
IS  - 1178-7031 (Electronic)
IS  - 1178-7031 (Linking)
VI  - 7
DP  - 2013
TI  - Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in 
      women who have undergone bilateral salpingo-oophorectomy.
PG  - 1-7
LID - 10.2147/JIR.S52728 [doi]
AB  - PURPOSE: The aim of the study reported here was to determine the effect of 
      surgical menopause by bilateral salpingo-oophorectomy (BSO) on circulating levels 
      of cytokines and chemokines related to the pathogenesis of atherosclerosis. 
      PATIENTS AND METHODS: A total of 110 women were recruited for this study from the 
      outpatient clinic of our facility. We divided the women into three groups: 1) 
      women with a regular menstrual cycle, 2) women in whom less than 5 years had 
      passed since their BSO, and 3) women in whom 5 years or more had passed since 
      their BSO. Concentrations of nine cytokines and chemokines in serum were 
      measured. RESULTS: The serum monocyte chemoattractant protein-1 (MCP-1) level in 
      women in whom less than 5 years had passed since their BSO was significantly 
      higher than in women with a regular menstrual cycle (P<0.05). There were 
      significant differences in serum interleukin (IL)-7 among the three groups 
      (P=0.035). MCP-1 showed a significant positive correlation (r=0.320, P=0.008) 
      with follicle-stimulating hormone in women with a regular menstrual cycle and in 
      women in whom less than 5 years had passed since their BSO. CONCLUSION: A 
      hypoestrogenic state due to BSO induced changes in MCP-1 and IL-7 levels. MCP-1 
      level showed a significant increase in the early period after BSO, while IL-7 
      level showed a significant decrease in the late period after BSO.
FAU - Tani, Anna
AU  - Tani A
AD  - Department of Obstetrics and Gynecology, Tokushima, Japan.
FAU - Yasui, Toshiyuki
AU  - Yasui T
AD  - Department of Reproductive Technology, Institute of health Biosciences, The 
      University of Tokushima Graduate School, Tokushima, Japan.
FAU - Matsui, Sumika
AU  - Matsui S
AD  - Department of Obstetrics and Gynecology, Tokushima, Japan.
FAU - Kato, Takeshi
AU  - Kato T
AD  - Department of Obstetrics and Gynecology, Tokushima, Japan.
FAU - Tsuchiya, Naoko
AU  - Tsuchiya N
AD  - Pharmacology Research Department, Tsumura Central Research Institute, Ibaraki, 
      Japan.
FAU - Yuzurihara, Mitsutoshi
AU  - Yuzurihara M
AD  - Pharmacology Research Department, Tsumura Central Research Institute, Ibaraki, 
      Japan.
FAU - Kase, Yoshio
AU  - Kase Y
AD  - Pharmacology Research Department, Tsumura Central Research Institute, Ibaraki, 
      Japan.
FAU - Irahara, Minoru
AU  - Irahara M
AD  - Department of Obstetrics and Gynecology, Tokushima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20131227
PL  - New Zealand
TA  - J Inflamm Res
JT  - Journal of inflammation research
JID - 101512684
PMC - PMC3881980
OTO - NOTNLM
OT  - chemokines
OT  - cytokines
OT  - follicle-stimulating hormone
OT  - hypoestrogenism
OT  - surgical menopause
EDAT- 2014/01/09 06:00
MHDA- 2014/01/09 06:01
PMCR- 2013/12/27
CRDT- 2014/01/09 06:00
PHST- 2014/01/09 06:00 [entrez]
PHST- 2014/01/09 06:00 [pubmed]
PHST- 2014/01/09 06:01 [medline]
PHST- 2013/12/27 00:00 [pmc-release]
AID - jir-7-001 [pii]
AID - 10.2147/JIR.S52728 [doi]
PST - epublish
SO  - J Inflamm Res. 2013 Dec 27;7:1-7. doi: 10.2147/JIR.S52728. eCollection 2013.